node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVL1 | DVL3 | ENSGALP00000002423 | ENSGALP00000045006 | Dishevelled segment polarity protein 1. | Dishevelled segment polarity protein 3. | 0.903 |
DVL1 | FZD1 | ENSGALP00000002423 | ENSGALP00000014736 | Dishevelled segment polarity protein 1. | Frizzled-1; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK [...] | 0.950 |
DVL1 | LRP6 | ENSGALP00000002423 | ENSGALP00000053042 | Dishevelled segment polarity protein 1. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.931 |
DVL1 | RYK | ENSGALP00000002423 | ENSGALP00000010474 | Dishevelled segment polarity protein 1. | Receptor like tyrosine kinase. | 0.473 |
DVL1 | WNT1 | ENSGALP00000002423 | ENSGALP00000071904 | Dishevelled segment polarity protein 1. | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity). | 0.718 |
DVL1 | WNT11 | ENSGALP00000002423 | ENSGALP00000001229 | Dishevelled segment polarity protein 1. | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. | 0.509 |
DVL1 | WNT5A | ENSGALP00000002423 | ENSGALP00000048027 | Dishevelled segment polarity protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.675 |
DVL1 | WNT5B | ENSGALP00000002423 | ENSGALP00000050737 | Dishevelled segment polarity protein 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.420 |
DVL3 | DVL1 | ENSGALP00000045006 | ENSGALP00000002423 | Dishevelled segment polarity protein 3. | Dishevelled segment polarity protein 1. | 0.903 |
DVL3 | FZD1 | ENSGALP00000045006 | ENSGALP00000014736 | Dishevelled segment polarity protein 3. | Frizzled-1; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK [...] | 0.969 |
DVL3 | LRP6 | ENSGALP00000045006 | ENSGALP00000053042 | Dishevelled segment polarity protein 3. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.967 |
DVL3 | RNF43 | ENSGALP00000045006 | ENSGALP00000001522 | Dishevelled segment polarity protein 3. | RING-type domain-containing protein. | 0.517 |
DVL3 | ROR2 | ENSGALP00000045006 | ENSGALP00000024493 | Dishevelled segment polarity protein 3. | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. | 0.485 |
DVL3 | RYK | ENSGALP00000045006 | ENSGALP00000010474 | Dishevelled segment polarity protein 3. | Receptor like tyrosine kinase. | 0.651 |
DVL3 | WNT1 | ENSGALP00000045006 | ENSGALP00000071904 | Dishevelled segment polarity protein 3. | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity). | 0.763 |
DVL3 | WNT11 | ENSGALP00000045006 | ENSGALP00000001229 | Dishevelled segment polarity protein 3. | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. | 0.684 |
DVL3 | WNT5A | ENSGALP00000045006 | ENSGALP00000048027 | Dishevelled segment polarity protein 3. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.767 |
DVL3 | WNT5B | ENSGALP00000045006 | ENSGALP00000050737 | Dishevelled segment polarity protein 3. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.514 |
FZD1 | DVL1 | ENSGALP00000014736 | ENSGALP00000002423 | Frizzled-1; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK [...] | Dishevelled segment polarity protein 1. | 0.950 |
FZD1 | DVL3 | ENSGALP00000014736 | ENSGALP00000045006 | Frizzled-1; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK [...] | Dishevelled segment polarity protein 3. | 0.969 |