node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC45 | CDC6 | ENSGALP00000002461 | ENSGALP00000067395 | Cell division cycle 45. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.991 |
CDC45 | CDT1 | ENSGALP00000002461 | ENSGALP00000022344 | Cell division cycle 45. | Chromatin licensing and DNA replication factor 1. | 0.994 |
CDC45 | MCM2 | ENSGALP00000002461 | ENSGALP00000009709 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC45 | MCM3 | ENSGALP00000002461 | ENSGALP00000026858 | Cell division cycle 45. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
CDC45 | MCM4 | ENSGALP00000002461 | ENSGALP00000021034 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC45 | MCM5 | ENSGALP00000002461 | ENSGALP00000020463 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC45 | MCM8 | ENSGALP00000002461 | ENSGALP00000014959 | Cell division cycle 45. | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.970 |
CDC45 | MCM9 | ENSGALP00000002461 | ENSGALP00000023968 | Cell division cycle 45. | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.974 |
CDC45 | MCMBP | ENSGALP00000002461 | ENSGALP00000037974 | Cell division cycle 45. | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). | 0.817 |
CDC45 | ORC2 | ENSGALP00000002461 | ENSGALP00000013386 | Cell division cycle 45. | Uncharacterized protein. | 0.939 |
CDC6 | CDC45 | ENSGALP00000067395 | ENSGALP00000002461 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 45. | 0.991 |
CDC6 | CDT1 | ENSGALP00000067395 | ENSGALP00000022344 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
CDC6 | MCM2 | ENSGALP00000067395 | ENSGALP00000009709 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM3 | ENSGALP00000067395 | ENSGALP00000026858 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
CDC6 | MCM4 | ENSGALP00000067395 | ENSGALP00000021034 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM5 | ENSGALP00000067395 | ENSGALP00000020463 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDC6 | MCM8 | ENSGALP00000067395 | ENSGALP00000014959 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.991 |
CDC6 | MCM9 | ENSGALP00000067395 | ENSGALP00000023968 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.976 |
CDC6 | MCMBP | ENSGALP00000067395 | ENSGALP00000037974 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). | 0.679 |
CDC6 | ORC2 | ENSGALP00000067395 | ENSGALP00000013386 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Uncharacterized protein. | 0.999 |