CDK6 protein (Gallus gallus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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Score

CDK6

Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)

Predicted Functional Partners:

CCND1

0.999

CCNA2

0.997

CCND3

0.995

RB1

0.995

CDKN2C

0.994

CCND2

0.994

CCNA1

0.992

CDKN2B

0.987

CDC25A

0.984

CDKN1B

0.979

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNA1	CCNA2	ENSGALP00000027497	ENSGALP00000019361	Cyclin A1; Belongs to the cyclin family.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.936
CCNA1	CCND1	ENSGALP00000027497	ENSGALP00000012203	Cyclin A1; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	0.477
CCNA1	CCND3	ENSGALP00000027497	ENSGALP00000005503	Cyclin A1; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.403
CCNA1	CDC25A	ENSGALP00000027497	ENSGALP00000057880	Cyclin A1; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.904
CCNA1	CDK6	ENSGALP00000027497	ENSGALP00000015412	Cyclin A1; Belongs to the cyclin family.	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.992
CCNA1	CDKN1B	ENSGALP00000027497	ENSGALP00000036494	Cyclin A1; Belongs to the cyclin family.	Cyclin-dependent kinase inhibitor p27 Kip1.	0.961
CCNA1	RB1	ENSGALP00000027497	ENSGALP00000071459	Cyclin A1; Belongs to the cyclin family.	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...]	0.978
CCNA2	CCNA1	ENSGALP00000019361	ENSGALP00000027497	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Cyclin A1; Belongs to the cyclin family.	0.936
CCNA2	CCND1	ENSGALP00000019361	ENSGALP00000012203	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	0.477
CCNA2	CCND2	ENSGALP00000019361	ENSGALP00000027885	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily.	0.419
CCNA2	CCND3	ENSGALP00000019361	ENSGALP00000005503	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.416
CCNA2	CDC25A	ENSGALP00000019361	ENSGALP00000057880	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Rhodanese domain-containing protein.	0.909
CCNA2	CDK6	ENSGALP00000019361	ENSGALP00000015412	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.997
CCNA2	CDKN1B	ENSGALP00000019361	ENSGALP00000036494	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Cyclin-dependent kinase inhibitor p27 Kip1.	0.974
CCNA2	RB1	ENSGALP00000019361	ENSGALP00000071459	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...]	0.986
CCND1	CCNA1	ENSGALP00000012203	ENSGALP00000027497	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	Cyclin A1; Belongs to the cyclin family.	0.477
CCND1	CCNA2	ENSGALP00000012203	ENSGALP00000019361	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.477
CCND1	CCND2	ENSGALP00000012203	ENSGALP00000027885	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily.	0.922
CCND1	CCND3	ENSGALP00000012203	ENSGALP00000005503	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.918
CCND1	CDC25A	ENSGALP00000012203	ENSGALP00000057880	G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).	Rhodanese domain-containing protein.	0.964