node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | COL1A1 | ENSGALP00000056897 | ENSGALP00000058148 | Link domain-containing protein. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.931 |
CD44 | COL1A2 | ENSGALP00000056897 | ENSGALP00000015687 | Link domain-containing protein. | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.917 |
CD44 | COL4A6 | ENSGALP00000056897 | ENSGALP00000072403 | Link domain-containing protein. | Collagen IV NC1 domain-containing protein. | 0.900 |
CD44 | ITGAV | ENSGALP00000056897 | ENSGALP00000047574 | Link domain-containing protein. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.520 |
CD44 | ITGB1 | ENSGALP00000056897 | ENSGALP00000054354 | Link domain-containing protein. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.516 |
CD44 | ITGB3 | ENSGALP00000056897 | ENSGALP00000000518 | Link domain-containing protein. | Integrin beta; Belongs to the integrin beta chain family. | 0.497 |
COL1A1 | CD44 | ENSGALP00000058148 | ENSGALP00000056897 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Link domain-containing protein. | 0.931 |
COL1A1 | COL1A2 | ENSGALP00000058148 | ENSGALP00000015687 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.747 |
COL1A1 | COL4A6 | ENSGALP00000058148 | ENSGALP00000072403 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen IV NC1 domain-containing protein. | 0.762 |
COL1A1 | COL5A1 | ENSGALP00000058148 | ENSGALP00000051075 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Fibrillar collagen NC1 domain-containing protein. | 0.703 |
COL1A1 | ITGA11 | ENSGALP00000058148 | ENSGALP00000012982 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. | 0.770 |
COL1A1 | ITGA8 | ENSGALP00000058148 | ENSGALP00000065785 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.692 |
COL1A1 | ITGAV | ENSGALP00000058148 | ENSGALP00000047574 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.712 |
COL1A1 | ITGB1 | ENSGALP00000058148 | ENSGALP00000054354 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.930 |
COL1A1 | ITGB3 | ENSGALP00000058148 | ENSGALP00000000518 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Integrin beta; Belongs to the integrin beta chain family. | 0.712 |
COL1A1 | POSTN | ENSGALP00000058148 | ENSGALP00000066072 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Uncharacterized protein. | 0.786 |
COL1A2 | CD44 | ENSGALP00000015687 | ENSGALP00000056897 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Link domain-containing protein. | 0.917 |
COL1A2 | COL1A1 | ENSGALP00000015687 | ENSGALP00000058148 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.747 |
COL1A2 | COL4A6 | ENSGALP00000015687 | ENSGALP00000072403 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen IV NC1 domain-containing protein. | 0.802 |
COL1A2 | COL5A1 | ENSGALP00000015687 | ENSGALP00000051075 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Fibrillar collagen NC1 domain-containing protein. | 0.797 |