STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)    
Predicted Functional Partners:
LYVE1
Link domain-containing protein.
   
  
 0.784
VEGFC
Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.
   
  
 0.710
PDPN
Uncharacterized protein.
      
 0.692
LHX3
LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2.
      
 0.630
LHX4
LIM homeobox 4.
      
 0.627
SOX18
Transcription factor SOX18.
   
  
 0.576
FLT4
Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      
 0.567
PAX6
Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.
   
 
 0.562
CCBE1
Collagen and calcium binding EGF domains 1.
      
 0.556
NR2F2
COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily.
   
 
 0.517
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.