STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
P2RY1P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity). (362 aa)    
Predicted Functional Partners:
P2RX1
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
      
 0.890
BRINP3
BMP/retinoic acid inducible neural specific 3.
      
 0.706
BRINP1
BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Has been shown to mediate cell death which is not of the classical apoptotic type and to regulate expression of components of the plasminogen pathway (By similarity); Belongs to the BRINP family.
      
 0.703
GNA11
Guanine nucleotide-binding protein G11 alpha-subunit.
    
 0.622
GNAQ
Uncharacterized protein.
    
 0.622
ANO8
Anoctamin.
      
 0.587
RGS18
RGS domain-containing protein.
   
 
  0.566
GNB1
WD_REPEATS_REGION domain-containing protein.
    
  0.562
GNB5
WD_REPEATS_REGION domain-containing protein.
    
  0.562
GNB3
G protein subunit beta 3.
    
  0.562
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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