node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | COL3A1 | ENSGALP00000056897 | ENSGALP00000051057 | Link domain-containing protein. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.908 |
CD44 | ITGA4 | ENSGALP00000056897 | ENSGALP00000053380 | Link domain-containing protein. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.653 |
CD44 | ITGAV | ENSGALP00000056897 | ENSGALP00000047574 | Link domain-containing protein. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.520 |
CD44 | ITGB1 | ENSGALP00000056897 | ENSGALP00000054354 | Link domain-containing protein. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.516 |
CD44 | ITGB3 | ENSGALP00000056897 | ENSGALP00000000518 | Link domain-containing protein. | Integrin beta; Belongs to the integrin beta chain family. | 0.497 |
CD44 | SPARC | ENSGALP00000056897 | ENSGALP00000006639 | Link domain-containing protein. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). | 0.407 |
CD44 | SPP1 | ENSGALP00000056897 | ENSGALP00000017754 | Link domain-containing protein. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.999 |
COL3A1 | CD44 | ENSGALP00000051057 | ENSGALP00000056897 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Link domain-containing protein. | 0.908 |
COL3A1 | ITGAV | ENSGALP00000051057 | ENSGALP00000047574 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.522 |
COL3A1 | ITGB1 | ENSGALP00000051057 | ENSGALP00000054354 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.792 |
COL3A1 | ITGB3 | ENSGALP00000051057 | ENSGALP00000000518 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Integrin beta; Belongs to the integrin beta chain family. | 0.642 |
COL3A1 | ITGB5 | ENSGALP00000051057 | ENSGALP00000047825 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Integrin beta; Belongs to the integrin beta chain family. | 0.529 |
COL3A1 | SPARC | ENSGALP00000051057 | ENSGALP00000006639 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). | 0.973 |
COL3A1 | SPP1 | ENSGALP00000051057 | ENSGALP00000017754 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.942 |
IRF7 | SPP1 | ENSGALP00000038233 | ENSGALP00000017754 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.917 |
ITGA4 | CD44 | ENSGALP00000053380 | ENSGALP00000056897 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Link domain-containing protein. | 0.653 |
ITGA4 | ITGA9 | ENSGALP00000053380 | ENSGALP00000055215 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | 0.561 |
ITGA4 | ITGAV | ENSGALP00000053380 | ENSGALP00000047574 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.693 |
ITGA4 | ITGB1 | ENSGALP00000053380 | ENSGALP00000054354 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.994 |
ITGA4 | ITGB3 | ENSGALP00000053380 | ENSGALP00000000518 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.862 |