STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIER1Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity). (530 aa)    
Predicted Functional Partners:
BAHD1
Bromo adjacent homology domain containing 1.
    
 
 0.892
CDYL
Chromo domain-containing protein.
   
 
 0.890
DIDO1
Death inducer-obliterator 1.
   
  
 0.713
PHF20L1
PHD finger protein 20-like protein 1.
   
  
 0.710
MEAF6
Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...]
   
  
 0.709
BCORL1
BCL6 corepressor like 1.
      
 0.702
ING3
Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity); Belongs to the ING family.
   
  
 0.672
ANAPC15
Anaphase promoting complex subunit 15.
      
 0.626
RAD23B
RAD23 homolog B, nucleotide excision repair protein.
   
  
 0.599
ZFX
Uncharacterized protein.
   
  
 0.570
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.