STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRYZPKS_ER domain-containing protein. (331 aa)    
Predicted Functional Partners:
HMOX1
Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
      
 0.859
GCLC
Glutamate-cysteine ligase catalytic subunit.
   
  
 0.815
RIDA
Reactive intermediate imine deaminase A homolog.
  
  
 0.739
NFE2L2
BZIP domain-containing protein.
      
 0.671
GPX1
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 
 0.632
GPX7
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 
 0.613
GPX4
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 
 0.613
GPX8
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 
 0.584
HSDL2
Hydroxysteroid dehydrogenase like 2.
  
 0.575
GSR
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 
 0.561
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.