CFI protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

CFI

Uncharacterized protein; Belongs to the peptidase S1 family. (596 aa)

Predicted Functional Partners:

C3

0.927

C4

0.861

C4A

0.829

MBL2

0.820

CFH

0.756

ENSGALP00000073524

0.742

C4BPA

0.714

C8A

0.666

SERPINA10

0.629

SERPING1

0.588

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	C4	ENSGALP00000049361	ENSGALP00000048078	Uncharacterized protein.	Uncharacterized protein.	0.525
C3	C4A	ENSGALP00000049361	ENSGALP00000056497	Uncharacterized protein.	Uncharacterized protein.	0.477
C3	C4BPA	ENSGALP00000049361	ENSGALP00000001779	Uncharacterized protein.	Uncharacterized protein.	0.777
C3	CFH	ENSGALP00000049361	ENSGALP00000064921	Uncharacterized protein.	Uncharacterized protein.	0.718
C3	CFI	ENSGALP00000049361	ENSGALP00000019783	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.927
C3	ENSGALP00000073524	ENSGALP00000049361	ENSGALP00000073524	Uncharacterized protein.	Uncharacterized protein.	0.779
C4	C3	ENSGALP00000048078	ENSGALP00000049361	Uncharacterized protein.	Uncharacterized protein.	0.525
C4	C4A	ENSGALP00000048078	ENSGALP00000056497	Uncharacterized protein.	Uncharacterized protein.	0.810
C4	C4BPA	ENSGALP00000048078	ENSGALP00000001779	Uncharacterized protein.	Uncharacterized protein.	0.766
C4	CFI	ENSGALP00000048078	ENSGALP00000019783	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.861
C4	ENSGALP00000073524	ENSGALP00000048078	ENSGALP00000073524	Uncharacterized protein.	Uncharacterized protein.	0.779
C4	MBL2	ENSGALP00000048078	ENSGALP00000040351	Uncharacterized protein.	Mannose-binding protein; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.	0.539
C4	SERPINA10	ENSGALP00000048078	ENSGALP00000017847	Uncharacterized protein.	Serpin family A member 10; Belongs to the serpin family.	0.419
C4A	C3	ENSGALP00000056497	ENSGALP00000049361	Uncharacterized protein.	Uncharacterized protein.	0.477
C4A	C4	ENSGALP00000056497	ENSGALP00000048078	Uncharacterized protein.	Uncharacterized protein.	0.810
C4A	C4BPA	ENSGALP00000056497	ENSGALP00000001779	Uncharacterized protein.	Uncharacterized protein.	0.766
C4A	C8A	ENSGALP00000056497	ENSGALP00000017612	Uncharacterized protein.	Complement C8 alpha chain.	0.477
C4A	CFI	ENSGALP00000056497	ENSGALP00000019783	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.829
C4A	ENSGALP00000073524	ENSGALP00000056497	ENSGALP00000073524	Uncharacterized protein.	Uncharacterized protein.	0.779
C4A	MBL2	ENSGALP00000056497	ENSGALP00000040351	Uncharacterized protein.	Mannose-binding protein; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.	0.654

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

9.22e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 298

1.49

3.05

1.60e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 167

1.75

4.58

1.39e-16

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

10 of 70

2.08

6.48

1.13e-17

GO:0005762

Mitochondrial large ribosomal subunit

8 of 41

2.22

6.13

8.87e-15

GO:0005840

Ribosome

11 of 183

1.71

4.42

6.79e-17

GO:0044391

Ribosomal subunit

10 of 154

1.74

4.31

4.98e-15

GO:0098798

Mitochondrial protein-containing complex

10 of 177

1.68

3.98

1.09e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4871

Organellar large ribosomal subunit, and Ribosomal protein L23

10 of 18

2.67

10.54

1.79e-22

CL:4863

Organellar ribosome

11 of 53

2.24

8.49

5.45e-22

CL:4893

Organellar large ribosomal subunit

5 of 6

2.85

5.39

7.63e-11

CL:4872

Mixed, incl. Ribosomal protein L23, and Organellar large ribosomal subunit

5 of 10

2.63

4.87

4.40e-10

CL:4874

Mixed, incl. Ribosomal protein L23, and Translation protein SH3-like domain superfamily

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 187

1.7

4.39

4.60e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

9 of 253

1.48

2.58

4.66e-10

MAP-392499

Metabolism of proteins

9 of 907

0.92

0.93

1.76e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005762

Mitochondrial large ribosomal subunit

9 of 38

2.3

7.35

1.68e-17

GOCC:0005761

Mitochondrial ribosome

10 of 64

2.12

6.74

5.70e-18

GOCC:0044391

Ribosomal subunit

10 of 141

1.78

4.55

1.97e-15

GOCC:0098798

Mitochondrial protein complex

10 of 168

1.7

4.12

5.94e-15

GOCC:0005739

Mitochondrion

11 of 684

1.13

1.66

3.63e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 92

1.81

3.45

9.56e-10

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