Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NEMFUncharacterized protein. (1071 aa)    
Predicted Functional Partners:
TCF25
Transcription factor 25.
   
 0.994
LTN1
E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family.
   
 0.994
ANKZF1
Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1.
   
 
 0.973
DKC1
H/ACA ribonucleoprotein complex subunit DKC1; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance; Belongs to the pseudouridine synthase TruB family.
   
   0.863
RPL8
Ribosomal_L2_C domain-containing protein.
    
  0.851
RPL18A
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
    
  0.840
RPL3
Uncharacterized protein; Belongs to the universal ribosomal protein uL3 family.
    
 0.838
RPL7
60S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. May play a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family.
    
 0.814
THOC2
THO complex 2.
   
    0.807
RPL30
60S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family.
    
  0.803
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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