STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LATS1Large tumor suppressor kinase 1. (1137 aa)    
Predicted Functional Partners:
MOB1B
MOB kinase activator 1B.
   
 0.995
MOB1A
MOB kinase activator 1A.
    
 0.993
SAV1
Salvador family WW domain containing protein 1.
    
 0.989
NF2
FERM domain-containing protein.
    
 
 0.975
YAP1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family.
   
 0.961
WWTR1
WW domain containing transcription regulator 1.
    
 0.913
AMOT
Angiomotin.
    
 0.901
TEAD1
TEA domain-containing protein.
   
 
 0.882
NF2L
FERM domain-containing protein.
    
 
 0.876
AMOTL2
Angiomotin like 2.
   
 0.850
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.