Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KCNJ3G protein-activated inward rectifier potassium channel 1; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating t [...] (492 aa)    
Predicted Functional Partners:
KCNJ5
Potassium voltage-gated channel subfamily J member 5.
  
0.985
KCNA5
Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.
      
 0.760
GNB3
G protein subunit beta 3.
   
 0.713
GALNT13
Polypeptide N-acetylgalactosaminyltransferase.
   
  
 0.705
PRPF40A
Pre-mRNA processing factor 40 homolog A.
   
  
 0.673
GABBR2
Gamma-aminobutyric acid type B receptor subunit 2.
   
 0.667
GNB4
G protein subunit beta 4.
    
 0.652
IRX4
Iroquois-class homeodomain protein IRX-4; Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart; Belongs to the TALE/IRO homeobox family.
   
  
 0.616
HTR1F
5-hydroxytryptamine receptor 1F.
   
  
 0.602
KCNJ4
Potassium voltage-gated channel subfamily J member 4.
  
 
0.597
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.