BID protein (Gallus gallus) - STRING interaction network

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Score

BID

BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa)

Predicted Functional Partners:

BAK1

0.995

BCL2

0.989

BCL2L1

0.979

CASP8

0.968

CASP18

0.968

MCL1

0.946

CASP2

0.937

CTSS

0.922

BCL2A1

0.916

CAPN2

0.912

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2	ENSGALP00000055311	ENSGALP00000020984	Uncharacterized protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.985
BAK1	BCL2A1	ENSGALP00000055311	ENSGALP00000010509	Uncharacterized protein.	Protein A1.	0.937
BAK1	BCL2L1	ENSGALP00000055311	ENSGALP00000054103	Uncharacterized protein.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.996
BAK1	BID	ENSGALP00000055311	ENSGALP00000048995	Uncharacterized protein.	BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).	0.995
BAK1	CAPN2	ENSGALP00000055311	ENSGALP00000015229	Uncharacterized protein.	Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.	0.901
BAK1	CASP18	ENSGALP00000055311	ENSGALP00000065273	Uncharacterized protein.	Initiator caspase; Belongs to the peptidase C14A family.	0.569
BAK1	CASP8	ENSGALP00000055311	ENSGALP00000013591	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.669
BAK1	MCL1	ENSGALP00000055311	ENSGALP00000062575	Uncharacterized protein.	Uncharacterized protein.	0.931
BCL2	BAK1	ENSGALP00000020984	ENSGALP00000055311	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.985
BCL2	BCL2L1	ENSGALP00000020984	ENSGALP00000054103	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.972
BCL2	BID	ENSGALP00000020984	ENSGALP00000048995	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).	0.989
BCL2	CASP18	ENSGALP00000020984	ENSGALP00000065273	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Initiator caspase; Belongs to the peptidase C14A family.	0.967
BCL2	CASP2	ENSGALP00000020984	ENSGALP00000029853	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.767
BCL2	CASP8	ENSGALP00000020984	ENSGALP00000013591	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C14A family.	0.967
BCL2	CTSS	ENSGALP00000020984	ENSGALP00000065590	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C1 family.	0.934
BCL2	MCL1	ENSGALP00000020984	ENSGALP00000062575	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.626
BCL2A1	BAK1	ENSGALP00000010509	ENSGALP00000055311	Protein A1.	Uncharacterized protein.	0.937
BCL2A1	BID	ENSGALP00000010509	ENSGALP00000048995	Protein A1.	BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).	0.916
BCL2A1	CASP8	ENSGALP00000010509	ENSGALP00000013591	Protein A1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.414
BCL2L1	BAK1	ENSGALP00000054103	ENSGALP00000055311	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Uncharacterized protein.	0.996

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