node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
INPP5A | IPMK | ENSGALP00000057560 | ENSGALP00000004267 | Inositol polyphosphate-5-phosphatase A. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.910 |
INPP5A | ITPR1 | ENSGALP00000057560 | ENSGALP00000072224 | Inositol polyphosphate-5-phosphatase A. | Uncharacterized protein. | 0.508 |
INPP5A | MINPP1 | ENSGALP00000057560 | ENSGALP00000005852 | Inositol polyphosphate-5-phosphatase A. | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | 0.915 |
INPP5A | PLCZ1 | ENSGALP00000057560 | ENSGALP00000021386 | Inositol polyphosphate-5-phosphatase A. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] | 0.913 |
IPMK | INPP5A | ENSGALP00000004267 | ENSGALP00000057560 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol polyphosphate-5-phosphatase A. | 0.910 |
IPMK | MINPP1 | ENSGALP00000004267 | ENSGALP00000005852 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | 0.961 |
IPMK | PLCZ1 | ENSGALP00000004267 | ENSGALP00000021386 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] | 0.911 |
ITPR1 | INPP5A | ENSGALP00000072224 | ENSGALP00000057560 | Uncharacterized protein. | Inositol polyphosphate-5-phosphatase A. | 0.508 |
ITPR1 | ITPR2 | ENSGALP00000072224 | ENSGALP00000022744 | Uncharacterized protein. | Inositol 1,4,5-trisphosphate receptor type 2. | 0.902 |
ITPR1 | PLCZ1 | ENSGALP00000072224 | ENSGALP00000021386 | Uncharacterized protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] | 0.909 |
ITPR1 | PRKCA | ENSGALP00000072224 | ENSGALP00000041561 | Uncharacterized protein. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.912 |
ITPR1 | PRKCB | ENSGALP00000072224 | ENSGALP00000056743 | Uncharacterized protein. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.912 |
ITPR2 | ITPR1 | ENSGALP00000022744 | ENSGALP00000072224 | Inositol 1,4,5-trisphosphate receptor type 2. | Uncharacterized protein. | 0.902 |
ITPR2 | PLCZ1 | ENSGALP00000022744 | ENSGALP00000021386 | Inositol 1,4,5-trisphosphate receptor type 2. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] | 0.950 |
ITPR2 | PRKCA | ENSGALP00000022744 | ENSGALP00000041561 | Inositol 1,4,5-trisphosphate receptor type 2. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.912 |
ITPR2 | PRKCB | ENSGALP00000022744 | ENSGALP00000056743 | Inositol 1,4,5-trisphosphate receptor type 2. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.912 |
MINPP1 | INPP5A | ENSGALP00000005852 | ENSGALP00000057560 | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | Inositol polyphosphate-5-phosphatase A. | 0.915 |
MINPP1 | IPMK | ENSGALP00000005852 | ENSGALP00000004267 | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.961 |
MINPP1 | PLCZ1 | ENSGALP00000005852 | ENSGALP00000021386 | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] | 0.900 |
MINPP1 | PTEN | ENSGALP00000005852 | ENSGALP00000005747 | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hyper [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.437 |