STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSRRTyrosine-protein kinase receptor. (1333 aa)    
Predicted Functional Partners:
INS
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.965
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.908
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.906
IRS1
Insulin receptor substrate 1.
   
 
 0.706
EGF
Uncharacterized protein.
    
 0.704
FGF9
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
     
 0.694
PDGFC
Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity).
     
 0.692
PDGFB
PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.
   
 
 0.687
FGF16
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
     
 0.666
FGF20
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
     
 0.666
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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