STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAX2Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (228 aa)    
Predicted Functional Partners:
SIX3
Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...]
      
 0.817
NEUROD1
Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
   
  
 0.716
ZPR1
ZPR1 zinc finger.
      
 0.701
ATOH7
Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3.
   
  
 0.654
DNAJC2
Uncharacterized protein.
      
 0.588
SIX6
Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family.
   
  
 0.566
PAX2
Paired-box containing protein Pax-2.
    
 
 0.546
GLUL
Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia. Also acts as glutamate decarboxylase by catalyzing the production of 4- aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner.
      
 0.511
NR2E1
Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation (By similarity). Involved in the regulation of retinal development; Belongs to the nuclear hormone receptor family. NR2 subfamily.
      
 0.500
HUC
RRM domain-containing protein.
      
 0.499
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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