STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM172ACotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. (416 aa)    
Predicted Functional Partners:
SLF1
SMC5-SMC6 complex localization factor 1.
   
  
 0.860
MCTP1
Multiple C2 and transmembrane domain containing 1.
      
 0.782
DCUN1D3
Defective in cullin neddylation 1 domain containing 3.
      
 0.713
MVB12A
Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
      
 0.706
CNTN5
Contactin-5; Contactins mediate cell surface interactions during nervous system development. May contribute to the formation of somatotopic maps of cerebellar afferents during the development of the nervous system. Belongs to the immunoglobulin superfamily. Contactin family.
      
 0.601
HDDC2
HD domain-containing protein.
      
 0.595
LRP8
Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...]
      
 0.531
CNTN1
Contactin-1; Mediates cell surface interactions during nervous system development. Interaction with TNR enhances the neurite outgrowth. Belongs to the immunoglobulin superfamily. Contactin family.
   
  
 0.501
CDH7
Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
      
 0.478
SLC12A7
Uncharacterized protein.
      
 0.474
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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