| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDT1 | MCM3 | ENSGALP00000022344 | ENSGALP00000026858 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
| CDT1 | MCM4 | ENSGALP00000022344 | ENSGALP00000021034 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.998 |
| CDT1 | MCM5 | ENSGALP00000022344 | ENSGALP00000020463 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM8 | ENSGALP00000022344 | ENSGALP00000014959 | Chromatin licensing and DNA replication factor 1. | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.967 |
| CDT1 | MCM9 | ENSGALP00000022344 | ENSGALP00000023968 | Chromatin licensing and DNA replication factor 1. | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.974 |
| CDT1 | MCMBP | ENSGALP00000022344 | ENSGALP00000037974 | Chromatin licensing and DNA replication factor 1. | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). | 0.850 |
| CDT1 | MSH2 | ENSGALP00000022344 | ENSGALP00000014557 | Chromatin licensing and DNA replication factor 1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.462 |
| CDT1 | POLA1 | ENSGALP00000022344 | ENSGALP00000067767 | Chromatin licensing and DNA replication factor 1. | DNA polymerase. | 0.545 |
| MCM3 | CDT1 | ENSGALP00000026858 | ENSGALP00000022344 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Chromatin licensing and DNA replication factor 1. | 0.999 |
| MCM3 | MCM4 | ENSGALP00000026858 | ENSGALP00000021034 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM3 | MCM5 | ENSGALP00000026858 | ENSGALP00000020463 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM3 | MCM8 | ENSGALP00000026858 | ENSGALP00000014959 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.991 |
| MCM3 | MCM9 | ENSGALP00000026858 | ENSGALP00000023968 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.996 |
| MCM3 | MCMBP | ENSGALP00000026858 | ENSGALP00000037974 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). | 0.999 |
| MCM3 | MMS22L | ENSGALP00000026858 | ENSGALP00000024966 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. | 0.926 |
| MCM3 | POLA1 | ENSGALP00000026858 | ENSGALP00000067767 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA polymerase. | 0.981 |
| MCM4 | CDT1 | ENSGALP00000021034 | ENSGALP00000022344 | DNA helicase; Belongs to the MCM family. | Chromatin licensing and DNA replication factor 1. | 0.998 |
| MCM4 | MCM3 | ENSGALP00000021034 | ENSGALP00000026858 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
| MCM4 | MCM5 | ENSGALP00000021034 | ENSGALP00000020463 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM4 | MCM8 | ENSGALP00000021034 | ENSGALP00000014959 | DNA helicase; Belongs to the MCM family. | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. | 0.937 |
