node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS5 | COL10A1 | ENSGALP00000025424 | ENSGALP00000024087 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | 0.701 |
ADAMTS5 | IHH | ENSGALP00000025424 | ENSGALP00000018493 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.592 |
ADAMTS5 | MMP13 | ENSGALP00000025424 | ENSGALP00000027710 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | ZnMc domain-containing protein. | 0.881 |
ADAMTS5 | RUNX2 | ENSGALP00000025424 | ENSGALP00000050655 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Runt-related transcription factor. | 0.675 |
ADAMTS5 | SOX9 | ENSGALP00000025424 | ENSGALP00000037718 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.545 |
ALPL | COL10A1 | ENSGALP00000038334 | ENSGALP00000024087 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | 0.692 |
ALPL | IHH | ENSGALP00000038334 | ENSGALP00000018493 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.476 |
ALPL | RUNX2 | ENSGALP00000038334 | ENSGALP00000050655 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Runt-related transcription factor. | 0.751 |
COL10A1 | ADAMTS5 | ENSGALP00000024087 | ENSGALP00000025424 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.701 |
COL10A1 | ALPL | ENSGALP00000024087 | ENSGALP00000038334 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | 0.692 |
COL10A1 | COL4A6 | ENSGALP00000024087 | ENSGALP00000072403 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Collagen IV NC1 domain-containing protein. | 0.667 |
COL10A1 | IHH | ENSGALP00000024087 | ENSGALP00000018493 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.845 |
COL10A1 | MMP13 | ENSGALP00000024087 | ENSGALP00000027710 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | ZnMc domain-containing protein. | 0.795 |
COL10A1 | PTHLH | ENSGALP00000024087 | ENSGALP00000069044 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. | 0.746 |
COL10A1 | RUNX2 | ENSGALP00000024087 | ENSGALP00000050655 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Runt-related transcription factor. | 0.851 |
COL10A1 | SOX5 | ENSGALP00000024087 | ENSGALP00000043607 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Transcription factor LSox5-II. | 0.684 |
COL10A1 | SOX6 | ENSGALP00000024087 | ENSGALP00000009790 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | HMG box domain-containing protein. | 0.678 |
COL10A1 | SOX9 | ENSGALP00000024087 | ENSGALP00000037718 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.842 |
COL4A6 | COL10A1 | ENSGALP00000072403 | ENSGALP00000024087 | Collagen IV NC1 domain-containing protein. | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | 0.667 |
IHH | ADAMTS5 | ENSGALP00000018493 | ENSGALP00000025424 | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.592 |