node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EMX2 | GPR156 | ENSGALP00000067273 | ENSGALP00000024104 | Empty spiracles homeobox 2. | G protein-coupled receptor 156. | 0.665 |
EMX2 | GPSM2 | ENSGALP00000067273 | ENSGALP00000003253 | Empty spiracles homeobox 2. | G protein signaling modulator 2. | 0.423 |
ENSGALP00000070753 | GABBR2 | ENSGALP00000070753 | ENSGALP00000046555 | ANF_receptor domain-containing protein. | Gamma-aminobutyric acid type B receptor subunit 2. | 0.900 |
ENSGALP00000070753 | GPR156 | ENSGALP00000070753 | ENSGALP00000024104 | ANF_receptor domain-containing protein. | G protein-coupled receptor 156. | 0.553 |
ENSGALP00000070753 | GPSM2 | ENSGALP00000070753 | ENSGALP00000003253 | ANF_receptor domain-containing protein. | G protein signaling modulator 2. | 0.400 |
FZD3 | FZD6 | ENSGALP00000043647 | ENSGALP00000071859 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.581 |
FZD3 | GPR156 | ENSGALP00000043647 | ENSGALP00000024104 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | G protein-coupled receptor 156. | 0.683 |
FZD3 | PTK7 | ENSGALP00000043647 | ENSGALP00000014004 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. | 0.751 |
FZD3 | VANGL1 | ENSGALP00000043647 | ENSGALP00000024186 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Vang-like protein. | 0.815 |
FZD6 | FZD3 | ENSGALP00000071859 | ENSGALP00000043647 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.581 |
FZD6 | GPR156 | ENSGALP00000071859 | ENSGALP00000024104 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | G protein-coupled receptor 156. | 0.542 |
FZD6 | PTK7 | ENSGALP00000071859 | ENSGALP00000014004 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. | 0.680 |
FZD6 | VANGL1 | ENSGALP00000071859 | ENSGALP00000024186 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Vang-like protein. | 0.914 |
GABBR2 | ENSGALP00000070753 | ENSGALP00000046555 | ENSGALP00000070753 | Gamma-aminobutyric acid type B receptor subunit 2. | ANF_receptor domain-containing protein. | 0.900 |
GABBR2 | GPR156 | ENSGALP00000046555 | ENSGALP00000024104 | Gamma-aminobutyric acid type B receptor subunit 2. | G protein-coupled receptor 156. | 0.553 |
GABBR2 | GPSM2 | ENSGALP00000046555 | ENSGALP00000003253 | Gamma-aminobutyric acid type B receptor subunit 2. | G protein signaling modulator 2. | 0.400 |
GPR156 | EMX2 | ENSGALP00000024104 | ENSGALP00000067273 | G protein-coupled receptor 156. | Empty spiracles homeobox 2. | 0.665 |
GPR156 | ENSGALP00000070753 | ENSGALP00000024104 | ENSGALP00000070753 | G protein-coupled receptor 156. | ANF_receptor domain-containing protein. | 0.553 |
GPR156 | FZD3 | ENSGALP00000024104 | ENSGALP00000043647 | G protein-coupled receptor 156. | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.683 |
GPR156 | FZD6 | ENSGALP00000024104 | ENSGALP00000071859 | G protein-coupled receptor 156. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.542 |