STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR156G protein-coupled receptor 156. (691 aa)    
Predicted Functional Partners:
GPSM2
G protein signaling modulator 2.
      
 0.843
FZD3
Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]
   
  
 0.683
EMX2
Empty spiracles homeobox 2.
      
 0.665
GABBR2
Gamma-aminobutyric acid type B receptor subunit 2.
     
0.553
ENSGALP00000070753
ANF_receptor domain-containing protein.
     
 0.553
VANGL1
Vang-like protein.
    
 
 0.543
FZD6
Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]
      
 0.542
PTK7
Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
      
 0.534
GPR158
G_PROTEIN_RECEP_F3_4 domain-containing protein.
   
  
 0.529
GPR18
G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family.
      
 0.529
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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