STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1864 aa)    
Predicted Functional Partners:
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
    
  0.752
LY6EL
UPAR/Ly6 domain-containing protein.
     
  0.750
NR1D1
Nuclear receptor subfamily 1 group D member 1.
      
 0.596
BCL2L14
Uncharacterized protein.
      
 0.539
SCG5
Uncharacterized protein.
   
 
 0.537
MAP1LC3C
Microtubule associated protein 1 light chain 3 gamma.
   
  
 0.532
THOC2
THO complex 2.
      
 0.532
HOMER3-2
WH1 domain-containing protein.
      
 0.508
GDF11
Growth differentiation factor 11.
    
 
 0.497
BSND
Uncharacterized protein.
      
 0.496
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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