TRIM14 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TRIM14

Uncharacterized protein. (433 aa)

Predicted Functional Partners:

SHB

0.841

RNF38

0.794

PPP6C

0.741

USP14

0.739

NANS

0.707

FAM174A

0.706

RIOK2

0.672

MAVS

0.625

GNE

0.603

SLCO4C1

0.590

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM174A	GNE	ENSGALP00000043294	ENSGALP00000024699	Family with sequence similarity 174 member A.	Epimerase_2 domain-containing protein.	0.690
FAM174A	NANS	ENSGALP00000043294	ENSGALP00000024681	Family with sequence similarity 174 member A.	AFP-like domain-containing protein.	0.709
FAM174A	RIOK2	ENSGALP00000043294	ENSGALP00000024630	Family with sequence similarity 174 member A.	RIO domain-containing protein.	0.848
FAM174A	RNF38	ENSGALP00000043294	ENSGALP00000024668	Family with sequence similarity 174 member A.	Ring finger protein 38.	0.844
FAM174A	SHB	ENSGALP00000043294	ENSGALP00000041190	Family with sequence similarity 174 member A.	SH2 domain-containing protein.	0.843
FAM174A	SLCO4C1	ENSGALP00000043294	ENSGALP00000041068	Family with sequence similarity 174 member A.	Solute carrier organic anion transporter family member.	0.787
FAM174A	TRIM14	ENSGALP00000043294	ENSGALP00000024674	Family with sequence similarity 174 member A.	Uncharacterized protein.	0.706
GNE	FAM174A	ENSGALP00000024699	ENSGALP00000043294	Epimerase_2 domain-containing protein.	Family with sequence similarity 174 member A.	0.690
GNE	NANS	ENSGALP00000024699	ENSGALP00000024681	Epimerase_2 domain-containing protein.	AFP-like domain-containing protein.	0.995
GNE	RIOK2	ENSGALP00000024699	ENSGALP00000024630	Epimerase_2 domain-containing protein.	RIO domain-containing protein.	0.588
GNE	RNF38	ENSGALP00000024699	ENSGALP00000024668	Epimerase_2 domain-containing protein.	Ring finger protein 38.	0.773
GNE	SHB	ENSGALP00000024699	ENSGALP00000041190	Epimerase_2 domain-containing protein.	SH2 domain-containing protein.	0.766
GNE	SLCO4C1	ENSGALP00000024699	ENSGALP00000041068	Epimerase_2 domain-containing protein.	Solute carrier organic anion transporter family member.	0.515
GNE	TRIM14	ENSGALP00000024699	ENSGALP00000024674	Epimerase_2 domain-containing protein.	Uncharacterized protein.	0.603
MAVS	TRIM14	ENSGALP00000051532	ENSGALP00000024674	CARD_2 domain-containing protein.	Uncharacterized protein.	0.625
NANS	FAM174A	ENSGALP00000024681	ENSGALP00000043294	AFP-like domain-containing protein.	Family with sequence similarity 174 member A.	0.709
NANS	GNE	ENSGALP00000024681	ENSGALP00000024699	AFP-like domain-containing protein.	Epimerase_2 domain-containing protein.	0.995
NANS	RIOK2	ENSGALP00000024681	ENSGALP00000024630	AFP-like domain-containing protein.	RIO domain-containing protein.	0.669
NANS	RNF38	ENSGALP00000024681	ENSGALP00000024668	AFP-like domain-containing protein.	Ring finger protein 38.	0.810
NANS	SHB	ENSGALP00000024681	ENSGALP00000041190	AFP-like domain-containing protein.	SH2 domain-containing protein.	0.841

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 19

2.73

3.41

4.52e-07

GO:0008652

Cellular amino acid biosynthetic process

5 of 63

2.31

3.32

2.63e-07

GO:0019240

Citrulline biosynthetic process

3 of 3

3.41

3.11

2.40e-06

GO:0006591

Ornithine metabolic process

3 of 11

2.84

2.55

2.16e-05

GO:0006592

Ornithine biosynthetic process

2 of 2

3.41

1.9

0.00038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

2 of 2

3.41

1.65

0.0011

GO:0004349

Glutamate 5-kinase activity

2 of 2

3.41

1.65

0.0011

GO:0004128

cytochrome-b5 reductase activity, acting on NAD(P)H

2 of 2

3.41

1.65

0.0011

GO:0016491

Oxidoreductase activity

7 of 900

1.3

1.45

2.79e-05

GO:0036094

Small molecule binding

7 of 3203

0.75

0.49

0.0162

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 438

1.37

0.74

0.0229

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34185272

(2021) Potential application and beneficial effects of a marine microalgal biomass produced in a high-rate algal pond (HRAP) in diets of European sea bass, Dicentrarchus labrax.

2 of 2

3.41

1.33

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13676

Mixed, incl. Arginine biosynthesis, and Metal-dependent hydrolase, composite domain superfamily

10 of 63

2.61

10.16

4.57e-22

CL:13751

Mixed, incl. De novo UMP biosynthetic process, and Hydantoinase/dihydropyrimidinase

6 of 24

2.81

6.37

7.61e-13

CL:13760

Mixed, incl. De novo UMP biosynthetic process, and Protein transport protein Got1

5 of 13

2.99

5.62

3.87e-11

CL:13763

De novo UMP biosynthetic process, and Oxidoreductase FAD-binding domain

4 of 7

3.16

4.6

4.00e-09

CL:13680

Arginine biosynthesis, and Proline biosynthetic process

4 of 30

2.53

3.33

4.79e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl01230

Biosynthesis of amino acids

4 of 89

2.06

2.54

6.00e-06

onl00220

Arginine biosynthesis

2 of 26

2.29

1.36

0.0029

onl00520

Amino sugar and nucleotide sugar metabolism

2 of 54

1.98

1.07

0.0088

onl00330

Arginine and proline metabolism

2 of 54

1.98

1.07

0.0088

onl01100

Metabolic pathways

7 of 1655

1.03

1.04

5.48e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1480926

O2/CO2 exchange in erythrocytes

3 of 36

2.33

1.69

0.00067

MAP-1237044

Erythrocytes take up carbon dioxide and release oxygen

3 of 36

2.33

1.69

0.00067

MAP-70635

Urea cycle

2 of 9

2.75

1.31

0.0042

MAP-8964539

Glutamate and glutamine metabolism

2 of 22

2.37

1.09

0.0097

MAP-71291

Metabolism of amino acids and derivatives

4 of 380

1.43

1.03

0.0043

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

5 of 992

1.11

0.68

0.0165

GOCC:0005737

Cytoplasm

10 of 6894

0.57

0.4

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0285

Flavoprotein

5 of 68

2.27

3.84

1.54e-08

KW-0560

Oxidoreductase

6 of 226

1.83

3.12

2.17e-08

KW-0274

FAD

4 of 61

2.22

3.01

9.31e-07

KW-0521

NADP

3 of 35

2.34

2.36

3.07e-05

KW-0641

Proline biosynthesis

2 of 5

3.01

2.05

0.00019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

3 of 7

3.04

2.7

1.26e-05

PF00970

Oxidoreductase FAD-binding domain

2 of 2

3.41

1.67

0.00099

PF00696

Amino acid kinase family

2 of 2

3.41

1.67

0.00099

PF00171

Aldehyde dehydrogenase family

2 of 23

2.35

0.88

0.0246

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001433

Oxidoreductase FAD/NAD(P)-binding

3 of 7

3.04

2.47

3.24e-05

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

3 of 12

2.81

2.3

6.13e-05

IPR017938

Riboflavin synthase-like beta-barrel

3 of 12

2.81

2.3

6.13e-05

IPR017927

FAD-binding domain, ferredoxin reductase-type

3 of 12

2.81

2.3

6.13e-05

IPR041744

Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain

2 of 2

3.41

1.67

0.0010

(more ...)

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