NFKBIZ protein (Gallus gallus) - STRING interaction network

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NFKBIZ

ANK_REP_REGION domain-containing protein. (618 aa)

Predicted Functional Partners:

TNFAIP3

0.779

NFKBIA

0.611

TRAF3IP2

0.596

SOCS3

0.594

TIMM17B

0.583

SLC29A4

0.579

IRF1

0.570

IL6

0.531

ZC3H12D

0.523

FBXW9

0.521

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FBXW9	NFKBIZ	ENSGALP00000067821	ENSGALP00000024720	F-box domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.521
IL6	IRF1	ENSGALP00000068117	ENSGALP00000071265	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	0.701
IL6	NFKBIA	ENSGALP00000068117	ENSGALP00000041417	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.903
IL6	NFKBIZ	ENSGALP00000068117	ENSGALP00000024720	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	ANK_REP_REGION domain-containing protein.	0.531
IL6	SOCS3	ENSGALP00000068117	ENSGALP00000042295	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...]	0.921
IL6	TNFAIP3	ENSGALP00000068117	ENSGALP00000046998	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	TNF alpha induced protein 3.	0.638
IRF1	IL6	ENSGALP00000071265	ENSGALP00000068117	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.701
IRF1	NFKBIA	ENSGALP00000071265	ENSGALP00000041417	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.670
IRF1	NFKBIZ	ENSGALP00000071265	ENSGALP00000024720	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	ANK_REP_REGION domain-containing protein.	0.570
IRF1	SOCS3	ENSGALP00000071265	ENSGALP00000042295	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...]	0.706
IRF1	TNFAIP3	ENSGALP00000071265	ENSGALP00000046998	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	TNF alpha induced protein 3.	0.606
NFKBIA	IL6	ENSGALP00000041417	ENSGALP00000068117	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.903
NFKBIA	IRF1	ENSGALP00000041417	ENSGALP00000071265	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	0.670
NFKBIA	NFKBIZ	ENSGALP00000041417	ENSGALP00000024720	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	ANK_REP_REGION domain-containing protein.	0.611
NFKBIA	SOCS3	ENSGALP00000041417	ENSGALP00000042295	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...]	0.647
NFKBIA	TNFAIP3	ENSGALP00000041417	ENSGALP00000046998	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	TNF alpha induced protein 3.	0.866
NFKBIA	TRAF3IP2	ENSGALP00000041417	ENSGALP00000024187	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	SEFIR domain-containing protein.	0.631
NFKBIZ	FBXW9	ENSGALP00000024720	ENSGALP00000067821	ANK_REP_REGION domain-containing protein.	F-box domain-containing protein.	0.521
NFKBIZ	IL6	ENSGALP00000024720	ENSGALP00000068117	ANK_REP_REGION domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.531
NFKBIZ	IRF1	ENSGALP00000024720	ENSGALP00000071265	ANK_REP_REGION domain-containing protein.	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	0.570