NFKBIZ protein (Gallus gallus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

NFKBIZ

ANK_REP_REGION domain-containing protein. (618 aa)

Predicted Functional Partners:

TNFAIP3

0.765

AKIRIN2

0.762

SOCS3

0.612

CFAP221

0.610

TRAF3IP2

0.578

NFKBIA

0.568

SLC29A4

0.558

IRF1

0.555

NFKBIE

0.543

FBXW9

0.514

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKIRIN2	NFKBIZ	ENSGALP00000025418	ENSGALP00000024720	Akirin.	ANK_REP_REGION domain-containing protein.	0.762
CFAP221	NFKBIZ	ENSGALP00000019737	ENSGALP00000024720	Cilia and flagella associated protein 221.	ANK_REP_REGION domain-containing protein.	0.610
FBXW9	NFKBIZ	ENSGALP00000067821	ENSGALP00000024720	F-box domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.514
IRF1	NFKBIA	ENSGALP00000071265	ENSGALP00000041417	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.632
IRF1	NFKBIZ	ENSGALP00000071265	ENSGALP00000024720	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	ANK_REP_REGION domain-containing protein.	0.555
IRF1	SOCS3	ENSGALP00000071265	ENSGALP00000042295	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...]	0.794
IRF1	TNFAIP3	ENSGALP00000071265	ENSGALP00000046998	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	TNF alpha induced protein 3.	0.520
NFKBIA	IRF1	ENSGALP00000041417	ENSGALP00000071265	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	0.632
NFKBIA	NFKBIE	ENSGALP00000041417	ENSGALP00000069824	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	NFKB inhibitor epsilon.	0.948
NFKBIA	NFKBIZ	ENSGALP00000041417	ENSGALP00000024720	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	ANK_REP_REGION domain-containing protein.	0.568
NFKBIA	SOCS3	ENSGALP00000041417	ENSGALP00000042295	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...]	0.580
NFKBIA	TNFAIP3	ENSGALP00000041417	ENSGALP00000046998	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	TNF alpha induced protein 3.	0.838
NFKBIE	NFKBIA	ENSGALP00000069824	ENSGALP00000041417	NFKB inhibitor epsilon.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.948
NFKBIE	NFKBIZ	ENSGALP00000069824	ENSGALP00000024720	NFKB inhibitor epsilon.	ANK_REP_REGION domain-containing protein.	0.543
NFKBIZ	AKIRIN2	ENSGALP00000024720	ENSGALP00000025418	ANK_REP_REGION domain-containing protein.	Akirin.	0.762
NFKBIZ	CFAP221	ENSGALP00000024720	ENSGALP00000019737	ANK_REP_REGION domain-containing protein.	Cilia and flagella associated protein 221.	0.610
NFKBIZ	FBXW9	ENSGALP00000024720	ENSGALP00000067821	ANK_REP_REGION domain-containing protein.	F-box domain-containing protein.	0.514
NFKBIZ	IRF1	ENSGALP00000024720	ENSGALP00000071265	ANK_REP_REGION domain-containing protein.	Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family.	0.555
NFKBIZ	NFKBIA	ENSGALP00000024720	ENSGALP00000041417	ANK_REP_REGION domain-containing protein.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.568
NFKBIZ	NFKBIE	ENSGALP00000024720	ENSGALP00000069824	ANK_REP_REGION domain-containing protein.	NFKB inhibitor epsilon.	0.543