STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCXD2Phosphatidylinositol specific phospholipase C X domain containing 2. (334 aa)    
Predicted Functional Partners:
NPTXR
Neuronal pentraxin receptor.
      
 0.760
SGPP2
Sphingosine-1-phosphate phosphatase 2.
      
 0.710
DDRGK1
DDRGK domain containing 1.
 
      0.708
PDE1B
Phosphodiesterase 1B; Belongs to the cyclic nucleotide phosphodiesterase family.
      
 0.703
MAPKAPK3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
      
 0.601
NTSR1
Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.597
CACNA1G
Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]
      
 0.583
HSPB11
F5/8 type C domain-containing protein.
      
 0.534
MAPKAPK2
MAPK activated protein kinase 2; Belongs to the protein kinase superfamily.
      
 0.520
PRKD3
Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
      
 0.520
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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