node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP1B1 | EPHX1 | ENSGALP00000048510 | ENSGALP00000015099 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.972 |
CYP1B1 | GSTA4 | ENSGALP00000048510 | ENSGALP00000026285 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Glutathione S-transferase class-alpha. | 0.921 |
CYP1B1 | GSTO2 | ENSGALP00000048510 | ENSGALP00000013682 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.927 |
CYP1B1 | GSTT1 | ENSGALP00000048510 | ENSGALP00000010240 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Theta family. | 0.930 |
CYP1B1 | LOC396380 | ENSGALP00000048510 | ENSGALP00000026283 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Glutathione S-transferase 3; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. | 0.926 |
EPHX1 | CYP1B1 | ENSGALP00000015099 | ENSGALP00000048510 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.972 |
EPHX1 | GPX7 | ENSGALP00000015099 | ENSGALP00000017282 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.461 |
EPHX1 | GSR | ENSGALP00000015099 | ENSGALP00000047092 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.400 |
EPHX1 | GSTA4 | ENSGALP00000015099 | ENSGALP00000026285 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione S-transferase class-alpha. | 0.782 |
EPHX1 | GSTO2 | ENSGALP00000015099 | ENSGALP00000013682 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Uncharacterized protein. | 0.762 |
EPHX1 | GSTT1 | ENSGALP00000015099 | ENSGALP00000010240 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Theta family. | 0.771 |
EPHX1 | LOC396380 | ENSGALP00000015099 | ENSGALP00000026283 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | Glutathione S-transferase 3; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. | 0.816 |
GPX7 | EPHX1 | ENSGALP00000017282 | ENSGALP00000015099 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.461 |
GPX7 | GSR | ENSGALP00000017282 | ENSGALP00000047092 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.998 |
GPX7 | GSS | ENSGALP00000017282 | ENSGALP00000005180 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Glutathione synthetase. | 0.916 |
GPX7 | GSTA4 | ENSGALP00000017282 | ENSGALP00000026285 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Glutathione S-transferase class-alpha. | 0.936 |
GPX7 | GSTO2 | ENSGALP00000017282 | ENSGALP00000013682 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Uncharacterized protein. | 0.933 |
GPX7 | GSTT1 | ENSGALP00000017282 | ENSGALP00000010240 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Theta family. | 0.930 |
GPX7 | LOC396380 | ENSGALP00000017282 | ENSGALP00000026283 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Glutathione S-transferase 3; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. | 0.943 |
GPX7 | PRDX6 | ENSGALP00000017282 | ENSGALP00000004817 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.956 |