PNPLA4 protein (Gallus gallus) - STRING interaction network

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Score

PNPLA4

PNPLA domain-containing protein. (350 aa)

Predicted Functional Partners:

RDH11

0.916

RPE65

0.911

ERD2L

0.906

DHRS3

0.906

RDH10

0.906

SDR16C5

0.906

CYP26A1

0.903

DHRS4

0.901

DHRS9

0.900

CYP27C1

0.900

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP26A1	CYP27C1	ENSGALP00000045482	ENSGALP00000018780	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.938
CYP26A1	DHRS3	ENSGALP00000045482	ENSGALP00000059451	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein.	0.981
CYP26A1	DHRS4	ENSGALP00000045482	ENSGALP00000051044	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein.	0.931
CYP26A1	DHRS9	ENSGALP00000045482	ENSGALP00000017653	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.921
CYP26A1	ERD2L	ENSGALP00000045482	ENSGALP00000035958	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.924
CYP26A1	PNPLA4	ENSGALP00000045482	ENSGALP00000026775	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	PNPLA domain-containing protein.	0.903
CYP26A1	RDH10	ENSGALP00000045482	ENSGALP00000071776	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.987
CYP26A1	RDH11	ENSGALP00000045482	ENSGALP00000015508	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.962
CYP26A1	SDR16C5	ENSGALP00000045482	ENSGALP00000074252	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.945
CYP27C1	CYP26A1	ENSGALP00000018780	ENSGALP00000045482	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	0.938
CYP27C1	DHRS3	ENSGALP00000018780	ENSGALP00000059451	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.916
CYP27C1	DHRS4	ENSGALP00000018780	ENSGALP00000051044	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.918
CYP27C1	DHRS9	ENSGALP00000018780	ENSGALP00000017653	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.906
CYP27C1	ERD2L	ENSGALP00000018780	ENSGALP00000035958	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.916
CYP27C1	PNPLA4	ENSGALP00000018780	ENSGALP00000026775	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	PNPLA domain-containing protein.	0.900
CYP27C1	RDH10	ENSGALP00000018780	ENSGALP00000071776	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.920
CYP27C1	RDH11	ENSGALP00000018780	ENSGALP00000015508	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.930
CYP27C1	SDR16C5	ENSGALP00000018780	ENSGALP00000074252	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.916
DHRS3	CYP26A1	ENSGALP00000059451	ENSGALP00000045482	Uncharacterized protein.	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]	0.981
DHRS3	CYP27C1	ENSGALP00000059451	ENSGALP00000018780	Uncharacterized protein.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.916