STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFAP2BTranscription factor AP-2 beta. (449 aa)    
Predicted Functional Partners:
KCTD1
Potassium channel tetramerization domain containing 1.
   
 0.826
YEATS4
GAS41.
    
 0.784
TFAP2A
TF_AP-2 domain-containing protein.
  
 
0.755
ETS1
Transforming protein p68/c-ets-1; Probable transcription factor.
   
  
 0.687
SOX10
Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.
   
  
 0.671
FOXE3
Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis.
   
 
 0.591
CITED4
Cbp/p300-interacting transactivator 3; Acts as transcriptional coactivator. Enhances estrogen- dependent transactivation mediated by estrogen receptors.
    
 0.584
CITED2
Cited2/melanocyte specific gene-related gene 1 MRG1.
    
 0.575
ZIC1
Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
   
 
 0.571
TFAP2D
TF_AP-2 domain-containing protein.
  
0.558
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.