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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DNAJC3DnaJ homolog subfamily C member 3; May be involved in the unfolded protein response (UPR) during ER stress. (504 aa)    
Predicted Functional Partners:
DNAJB11
J domain-containing protein.
   
0.968
DNAJC10
DnaJ heat shock protein family (Hsp40) member C10.
   
0.960
EIF2AK2
Uncharacterized protein.
   
 0.957
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1.
   
0.915
PDIA6
Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.
   
 
 0.878
HYOU1
Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding; Belongs to the heat shock protein 70 family.
  
 0.860
HSP90B1
Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity).
  
 
 0.850
HSPA5
Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]
  
 0.812
SEC63
SEC63 homolog, protein translocation regulator.
   
 
 0.774
YIPF5
Protein YIPF.
   
  
 0.754
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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