node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL2 | SLITRK1 | ENSGALP00000056097 | ENSGALP00000027275 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | SLIT and NTRK like family member 1. | 0.693 |
ADGRL3 | SLITRK1 | ENSGALP00000043995 | ENSGALP00000027275 | Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. | SLIT and NTRK like family member 1. | 0.701 |
IL1RAPL1 | NTRK3 | ENSGALP00000026211 | ENSGALP00000049680 | Interleukin 1 receptor accessory protein like 1. | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | 0.701 |
IL1RAPL1 | PTPRD | ENSGALP00000026211 | ENSGALP00000051694 | Interleukin 1 receptor accessory protein like 1. | Protein tyrosine phosphatase receptor type D. | 0.918 |
IL1RAPL1 | PTPRF | ENSGALP00000026211 | ENSGALP00000057545 | Interleukin 1 receptor accessory protein like 1. | Protein tyrosine phosphatase receptor type F. | 0.607 |
IL1RAPL1 | PTPRS | ENSGALP00000026211 | ENSGALP00000056093 | Interleukin 1 receptor accessory protein like 1. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.893 |
IL1RAPL1 | SLITRK1 | ENSGALP00000026211 | ENSGALP00000027275 | Interleukin 1 receptor accessory protein like 1. | SLIT and NTRK like family member 1. | 0.812 |
KATNA1 | SLITRK1 | ENSGALP00000020184 | ENSGALP00000027275 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. | SLIT and NTRK like family member 1. | 0.627 |
LRRC34 | SLITRK1 | ENSGALP00000015298 | ENSGALP00000027275 | Leucine rich repeat containing 34. | SLIT and NTRK like family member 1. | 0.711 |
NTRK2 | NTRK3 | ENSGALP00000069010 | ENSGALP00000049680 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | 0.551 |
NTRK2 | SLITRK1 | ENSGALP00000069010 | ENSGALP00000027275 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] | SLIT and NTRK like family member 1. | 0.672 |
NTRK3 | IL1RAPL1 | ENSGALP00000049680 | ENSGALP00000026211 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Interleukin 1 receptor accessory protein like 1. | 0.701 |
NTRK3 | NTRK2 | ENSGALP00000049680 | ENSGALP00000069010 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] | 0.551 |
NTRK3 | PTPRD | ENSGALP00000049680 | ENSGALP00000051694 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Protein tyrosine phosphatase receptor type D. | 0.404 |
NTRK3 | PTPRS | ENSGALP00000049680 | ENSGALP00000056093 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] | 0.997 |
NTRK3 | SLITRK1 | ENSGALP00000049680 | ENSGALP00000027275 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | SLIT and NTRK like family member 1. | 0.669 |
PTPRD | IL1RAPL1 | ENSGALP00000051694 | ENSGALP00000026211 | Protein tyrosine phosphatase receptor type D. | Interleukin 1 receptor accessory protein like 1. | 0.918 |
PTPRD | NTRK3 | ENSGALP00000051694 | ENSGALP00000049680 | Protein tyrosine phosphatase receptor type D. | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] | 0.404 |
PTPRD | SLITRK1 | ENSGALP00000051694 | ENSGALP00000027275 | Protein tyrosine phosphatase receptor type D. | SLIT and NTRK like family member 1. | 0.893 |
PTPRF | IL1RAPL1 | ENSGALP00000057545 | ENSGALP00000026211 | Protein tyrosine phosphatase receptor type F. | Interleukin 1 receptor accessory protein like 1. | 0.607 |