node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPT1 | FGF2 | ENSGALP00000050106 | ENSGALP00000031519 | Fibrinogen C-terminal domain-containing protein. | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | 0.782 |
ANGPT1 | FLT1 | ENSGALP00000050106 | ENSGALP00000027556 | Fibrinogen C-terminal domain-containing protein. | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] | 0.926 |
ANGPT1 | NRP1 | ENSGALP00000050106 | ENSGALP00000063015 | Fibrinogen C-terminal domain-containing protein. | Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity); Belongs t [...] | 0.506 |
ANGPT1 | PGF | ENSGALP00000050106 | ENSGALP00000065908 | Fibrinogen C-terminal domain-containing protein. | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. | 0.692 |
ANGPT1 | VEGFA | ENSGALP00000050106 | ENSGALP00000066335 | Fibrinogen C-terminal domain-containing protein. | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). | 0.431 |
ANGPT1 | VEGFC | ENSGALP00000050106 | ENSGALP00000017608 | Fibrinogen C-terminal domain-containing protein. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.722 |
ANGPT1 | VEGFD | ENSGALP00000050106 | ENSGALP00000055963 | Fibrinogen C-terminal domain-containing protein. | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. | 0.602 |
ANGPT2 | FGF2 | ENSGALP00000064997 | ENSGALP00000031519 | Angiopoietin-2A. | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | 0.708 |
ANGPT2 | FLT1 | ENSGALP00000064997 | ENSGALP00000027556 | Angiopoietin-2A. | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] | 0.940 |
ANGPT2 | NRP1 | ENSGALP00000064997 | ENSGALP00000063015 | Angiopoietin-2A. | Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity); Belongs t [...] | 0.508 |
ANGPT2 | PGF | ENSGALP00000064997 | ENSGALP00000065908 | Angiopoietin-2A. | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. | 0.702 |
ANGPT2 | VEGFC | ENSGALP00000064997 | ENSGALP00000017608 | Angiopoietin-2A. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.773 |
ANGPT2 | VEGFD | ENSGALP00000064997 | ENSGALP00000055963 | Angiopoietin-2A. | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. | 0.518 |
FGF2 | ANGPT1 | ENSGALP00000031519 | ENSGALP00000050106 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Fibrinogen C-terminal domain-containing protein. | 0.782 |
FGF2 | ANGPT2 | ENSGALP00000031519 | ENSGALP00000064997 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Angiopoietin-2A. | 0.708 |
FGF2 | FLT1 | ENSGALP00000031519 | ENSGALP00000027556 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] | 0.926 |
FGF2 | NRP1 | ENSGALP00000031519 | ENSGALP00000063015 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity); Belongs t [...] | 0.656 |
FGF2 | PGF | ENSGALP00000031519 | ENSGALP00000065908 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. | 0.704 |
FGF2 | PTK2 | ENSGALP00000031519 | ENSGALP00000071114 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] | 0.485 |
FGF2 | VEGFA | ENSGALP00000031519 | ENSGALP00000066335 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). | 0.769 |