node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | COL10A1 | ENSGALP00000010867 | ENSGALP00000024087 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | 0.564 |
ACAN | COL3A1 | ENSGALP00000010867 | ENSGALP00000051057 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.990 |
ACAN | IHH | ENSGALP00000010867 | ENSGALP00000018493 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.787 |
ACAN | PTH2R | ENSGALP00000010867 | ENSGALP00000008782 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Parathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.422 |
ACAN | PTHLH | ENSGALP00000010867 | ENSGALP00000069044 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. | 0.701 |
ACAN | RUNX2 | ENSGALP00000010867 | ENSGALP00000050655 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Runt-related transcription factor. | 0.848 |
ACAN | SOX9 | ENSGALP00000010867 | ENSGALP00000037718 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.955 |
COL10A1 | ACAN | ENSGALP00000024087 | ENSGALP00000010867 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.564 |
COL10A1 | COL3A1 | ENSGALP00000024087 | ENSGALP00000051057 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.591 |
COL10A1 | IHH | ENSGALP00000024087 | ENSGALP00000018493 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.845 |
COL10A1 | PTH2R | ENSGALP00000024087 | ENSGALP00000008782 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Parathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.576 |
COL10A1 | PTHLH | ENSGALP00000024087 | ENSGALP00000069044 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. | 0.746 |
COL10A1 | RUNX2 | ENSGALP00000024087 | ENSGALP00000050655 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Runt-related transcription factor. | 0.851 |
COL10A1 | SOX9 | ENSGALP00000024087 | ENSGALP00000037718 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.842 |
COL3A1 | ACAN | ENSGALP00000051057 | ENSGALP00000010867 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.990 |
COL3A1 | COL10A1 | ENSGALP00000051057 | ENSGALP00000024087 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. | 0.591 |
COL3A1 | IHH | ENSGALP00000051057 | ENSGALP00000018493 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.784 |
COL3A1 | PTH | ENSGALP00000051057 | ENSGALP00000044567 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. | 0.764 |
COL3A1 | PTH2R | ENSGALP00000051057 | ENSGALP00000008782 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Parathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.478 |
COL3A1 | PTHLH | ENSGALP00000051057 | ENSGALP00000069044 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. | 0.747 |