TEAD4 protein (Gallus gallus) - STRING interaction network

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TEAD4

Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...] (445 aa)

Predicted Functional Partners:

YAP1

0.981

VGLL4

0.921

WWTR1

0.866

MCAT

0.773

VGLL1

0.734

LATS1

0.710

LATS2

0.677

INSM2

0.641

SAV1

0.611

AMOTL2

0.598

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOTL2	LATS1	ENSGALP00000072536	ENSGALP00000020194	Angiomotin like 2.	Large tumor suppressor kinase 1.	0.850
AMOTL2	LATS2	ENSGALP00000072536	ENSGALP00000074005	Angiomotin like 2.	Non-specific serine/threonine protein kinase.	0.897
AMOTL2	SAV1	ENSGALP00000072536	ENSGALP00000020137	Angiomotin like 2.	Salvador family WW domain containing protein 1.	0.677
AMOTL2	TEAD4	ENSGALP00000072536	ENSGALP00000023126	Angiomotin like 2.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.598
AMOTL2	WWTR1	ENSGALP00000072536	ENSGALP00000016933	Angiomotin like 2.	WW domain containing transcription regulator 1.	0.731
AMOTL2	YAP1	ENSGALP00000072536	ENSGALP00000053936	Angiomotin like 2.	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family.	0.843
INSM2	TEAD4	ENSGALP00000068474	ENSGALP00000023126	INSM transcriptional repressor 2.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.641
LATS1	AMOTL2	ENSGALP00000020194	ENSGALP00000072536	Large tumor suppressor kinase 1.	Angiomotin like 2.	0.850
LATS1	LATS2	ENSGALP00000020194	ENSGALP00000074005	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.794
LATS1	SAV1	ENSGALP00000020194	ENSGALP00000020137	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.989
LATS1	TEAD4	ENSGALP00000020194	ENSGALP00000023126	Large tumor suppressor kinase 1.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.710
LATS1	VGLL4	ENSGALP00000020194	ENSGALP00000007888	Large tumor suppressor kinase 1.	Uncharacterized protein.	0.710
LATS1	WWTR1	ENSGALP00000020194	ENSGALP00000016933	Large tumor suppressor kinase 1.	WW domain containing transcription regulator 1.	0.913
LATS1	YAP1	ENSGALP00000020194	ENSGALP00000053936	Large tumor suppressor kinase 1.	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family.	0.961
LATS2	AMOTL2	ENSGALP00000074005	ENSGALP00000072536	Non-specific serine/threonine protein kinase.	Angiomotin like 2.	0.897
LATS2	LATS1	ENSGALP00000074005	ENSGALP00000020194	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.794
LATS2	SAV1	ENSGALP00000074005	ENSGALP00000020137	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.983
LATS2	TEAD4	ENSGALP00000074005	ENSGALP00000023126	Non-specific serine/threonine protein kinase.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.677
LATS2	VGLL4	ENSGALP00000074005	ENSGALP00000007888	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.606
LATS2	WWTR1	ENSGALP00000074005	ENSGALP00000016933	Non-specific serine/threonine protein kinase.	WW domain containing transcription regulator 1.	0.909

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