STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INVSInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). (1113 aa)    
Predicted Functional Partners:
DVL3
Dishevelled segment polarity protein 3.
    
 0.966
DVL1
Dishevelled segment polarity protein 1.
    
 0.946
NEK8
NIMA related kinase 8.
   
 
 0.887
NPHP4
Nephrocystin 4.
      
 0.853
NPHP3
Uncharacterized protein.
   
 
 0.833
PRICKLE2
Prickle planar cell polarity protein 2.
    
 
 0.819
IFT88
Intraflagellar transport 88.
   
 
 0.791
PRICKLE1
Prickle planar cell polarity protein 1.
    
 
 0.779
NPHP1
SH3 domain-containing protein.
    
 
 0.778
VANGL1
Vang-like protein.
    
 
 0.745
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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