STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFB4AGallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. (64 aa)    
Predicted Functional Partners:
AvBD1
Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans.
   
 
 0.994
AvBD6
Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
   
 
 0.986
AvBD4
Gallinacin-4; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
   
 
 0.980
AvBD7
Gallinacin-7; Has bactericidal activity.
   
 
 0.978
AvBD3
Gallinacin-3; Has bactericidal activity.
     
 0.969
CAMP
Cathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
   
  
 0.928
AvBD5
Gallinacin-5; Has bactericidal activity.
   
 
 0.922
AvBD9
Gallinacin-9; Has bactericidal activity. Potent activity against C.jejuni, C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent against S.typhimurium and E.coli.
   
 
 0.917
AvBD8
Gallinacin-8; Has bactericidal activity.
   
 
 0.916
AvBD14
Gallinacin-14; Has bactericidal activity; Belongs to the beta-defensin family.
     
 0.903
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.