STRINGSTRING
FZD7 protein (Gallus gallus) - STRING interaction network
"FZD7" - Frizzled-7 in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FZD7Frizzled-7; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] (567 aa)    
Predicted Functional Partners:
WNT5A
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (385 aa)
     
  0.933
DVL3
Dishevelled segment polarity protein 3 (610 aa)
     
  0.931
WNT11
Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (326 aa)
       
  0.929
WNT3A
Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Isoform 1 regulates chick apical ectodermal ridge formation (352 aa)
     
  0.923
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes (1453 aa)
       
  0.915
WNT5B
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (358 aa)
     
  0.915
WNT7A
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (349 aa)
       
  0.906
DVL1
Dishevelled segment polarity protein 1 (529 aa)
     
  0.904
WNT4
Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors. May be an intracellular signaling molecule involved in segmentation of the forebrain into the neuromere D2 and in differentiation of the dorsal region of the spinal cord. Is likely to signal over only few cell diameters (351 aa)
     
  0.893
WNT2B
Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Signaling molecule which affects the development of discrete regions of tissues. Could participate in the process of blood vessel formation. Is likely to signal over only few cell diameters. May be involved in brain development and in later organogenesis. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo (441 aa)
     
  0.892
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (10%) [HD]