node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFIP2 | RABGAP1L | ENSGALP00000043736 | ENSGALP00000032966 | ADP ribosylation factor interacting protein 2. | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | 0.701 |
ARFIP2 | RABGAP1L-2 | ENSGALP00000043736 | ENSGALP00000056612 | ADP ribosylation factor interacting protein 2. | Rab GTPase-activating protein 1-like. | 0.703 |
ARFIP2 | USP43 | ENSGALP00000043736 | ENSGALP00000051115 | ADP ribosylation factor interacting protein 2. | Ubiquitin carboxyl-terminal hydrolase. | 0.819 |
DENND1A | RAB22A | ENSGALP00000058471 | ENSGALP00000012201 | DENN domain containing 1A. | Uncharacterized protein. | 0.415 |
DENND1A | RABGAP1L | ENSGALP00000058471 | ENSGALP00000032966 | DENN domain containing 1A. | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | 0.671 |
DENND1A | RABGAP1L-2 | ENSGALP00000058471 | ENSGALP00000056612 | DENN domain containing 1A. | Rab GTPase-activating protein 1-like. | 0.700 |
GPR21 | RABGAP1L | ENSGALP00000072124 | ENSGALP00000032966 | G protein-coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | 0.753 |
GPR21 | RC3H2 | ENSGALP00000072124 | ENSGALP00000001900 | G protein-coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. | Ring finger and CCCH-type domains 2. | 0.840 |
RAB22A | DENND1A | ENSGALP00000012201 | ENSGALP00000058471 | Uncharacterized protein. | DENN domain containing 1A. | 0.415 |
RAB22A | RABGAP1L | ENSGALP00000012201 | ENSGALP00000032966 | Uncharacterized protein. | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | 0.644 |
RAB22A | RABGAP1L-2 | ENSGALP00000012201 | ENSGALP00000056612 | Uncharacterized protein. | Rab GTPase-activating protein 1-like. | 0.682 |
RAB22A | TBCC | ENSGALP00000012201 | ENSGALP00000069224 | Uncharacterized protein. | Tubulin folding cofactor C. | 0.423 |
RABGAP1L | ARFIP2 | ENSGALP00000032966 | ENSGALP00000043736 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | ADP ribosylation factor interacting protein 2. | 0.701 |
RABGAP1L | DENND1A | ENSGALP00000032966 | ENSGALP00000058471 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | DENN domain containing 1A. | 0.671 |
RABGAP1L | GPR21 | ENSGALP00000032966 | ENSGALP00000072124 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | G protein-coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. | 0.753 |
RABGAP1L | RAB22A | ENSGALP00000032966 | ENSGALP00000012201 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | Uncharacterized protein. | 0.644 |
RABGAP1L | RABGAP1L-2 | ENSGALP00000032966 | ENSGALP00000056612 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | Rab GTPase-activating protein 1-like. | 0.900 |
RABGAP1L | RC3H2 | ENSGALP00000032966 | ENSGALP00000001900 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | Ring finger and CCCH-type domains 2. | 0.648 |
RABGAP1L | SMIM7 | ENSGALP00000032966 | ENSGALP00000050996 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | Uncharacterized protein. | 0.608 |
RABGAP1L | TBCC | ENSGALP00000032966 | ENSGALP00000069224 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] | Tubulin folding cofactor C. | 0.851 |