STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RABGAP1LRab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] (816 aa)    
Predicted Functional Partners:
RABGAP1L-2
Rab GTPase-activating protein 1-like.
 
      0.900
TBCC
Tubulin folding cofactor C.
   
  
 0.851
GPR21
G protein-coupled receptor 21; Belongs to the G-protein coupled receptor 1 family.
 
    
 0.753
USP43
Ubiquitin carboxyl-terminal hydrolase.
      
 0.705
ARFIP2
ADP ribosylation factor interacting protein 2.
      
 0.701
DENND1A
DENN domain containing 1A.
      
 0.671
RC3H2
Ring finger and CCCH-type domains 2.
   
  
 0.648
RAB22A
Uncharacterized protein.
    
 
 0.644
SMIM7
Uncharacterized protein.
      
 0.608
USE1
Uncharacterized protein.
   
  
 0.603
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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