STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UNC5BUncharacterized protein. (945 aa)    
Predicted Functional Partners:
NEO1
Neogenin; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
   
 
 0.984
NTN4L
Uncharacterized protein.
      
 0.931
NTN4
Netrin 4.
      
 0.931
NTN3
Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons.
    
 
 0.906
NTN1
Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
    
 
 0.903
FLRT3
Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...]
    
 
 0.887
DSCAM
Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...]
    
 
 0.768
RGMA
Repulsive guidance molecule A; Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.
      
 0.764
ROBO4
Uncharacterized protein.
      
 0.758
FLRT2
Fibronectin leucine rich transmembrane protein 2.
    
 
 0.676
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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