node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRS2 | GAB1 | ENSGALP00000016181 | ENSGALP00000049658 | IRS-type PTB domain-containing protein. | GRB2 associated binding protein 1. | 0.846 |
FRS2 | GAB2 | ENSGALP00000016181 | ENSGALP00000072661 | IRS-type PTB domain-containing protein. | GRB2 associated binding protein 2. | 0.557 |
FRS2 | GRB2 | ENSGALP00000016181 | ENSGALP00000012993 | IRS-type PTB domain-containing protein. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.988 |
FRS2 | LOC419429 | ENSGALP00000016181 | ENSGALP00000062318 | IRS-type PTB domain-containing protein. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.793 |
FRS2 | PTPN11 | ENSGALP00000016181 | ENSGALP00000007692 | IRS-type PTB domain-containing protein. | Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. | 0.906 |
FRS2 | SOS1 | ENSGALP00000016181 | ENSGALP00000051354 | IRS-type PTB domain-containing protein. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.909 |
GAB1 | FRS2 | ENSGALP00000049658 | ENSGALP00000016181 | GRB2 associated binding protein 1. | IRS-type PTB domain-containing protein. | 0.846 |
GAB1 | GAB2 | ENSGALP00000049658 | ENSGALP00000072661 | GRB2 associated binding protein 1. | GRB2 associated binding protein 2. | 0.544 |
GAB1 | GRB2 | ENSGALP00000049658 | ENSGALP00000012993 | GRB2 associated binding protein 1. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.999 |
GAB1 | LOC419429 | ENSGALP00000049658 | ENSGALP00000062318 | GRB2 associated binding protein 1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.926 |
GAB1 | PTPN11 | ENSGALP00000049658 | ENSGALP00000007692 | GRB2 associated binding protein 1. | Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. | 0.961 |
GAB1 | SOS1 | ENSGALP00000049658 | ENSGALP00000051354 | GRB2 associated binding protein 1. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.802 |
GAB2 | FRS2 | ENSGALP00000072661 | ENSGALP00000016181 | GRB2 associated binding protein 2. | IRS-type PTB domain-containing protein. | 0.557 |
GAB2 | GAB1 | ENSGALP00000072661 | ENSGALP00000049658 | GRB2 associated binding protein 2. | GRB2 associated binding protein 1. | 0.544 |
GAB2 | GRB2 | ENSGALP00000072661 | ENSGALP00000012993 | GRB2 associated binding protein 2. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.979 |
GAB2 | JAK2 | ENSGALP00000072661 | ENSGALP00000074116 | GRB2 associated binding protein 2. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.454 |
GAB2 | LOC419429 | ENSGALP00000072661 | ENSGALP00000062318 | GRB2 associated binding protein 2. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.776 |
GAB2 | PTPN11 | ENSGALP00000072661 | ENSGALP00000007692 | GRB2 associated binding protein 2. | Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. | 0.953 |
GAB2 | SOS1 | ENSGALP00000072661 | ENSGALP00000051354 | GRB2 associated binding protein 2. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.522 |
GAB2 | SYK | ENSGALP00000072661 | ENSGALP00000024509 | GRB2 associated binding protein 2. | Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] | 0.604 |