node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSE1L | KPNA1 | ENSGALP00000007487 | ENSGALP00000034376 | Chromosome segregation 1 like. | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | 0.969 |
CSE1L | KPNA3 | ENSGALP00000007487 | ENSGALP00000027423 | Chromosome segregation 1 like. | Importin subunit alpha; Belongs to the importin alpha family. | 0.968 |
CSE1L | KPNA4 | ENSGALP00000007487 | ENSGALP00000056543 | Chromosome segregation 1 like. | Importin subunit alpha; Belongs to the importin alpha family. | 0.966 |
CSE1L | KPNB1 | ENSGALP00000007487 | ENSGALP00000046659 | Chromosome segregation 1 like. | Karyopherin subunit beta 1. | 0.784 |
CSE1L | NUP50 | ENSGALP00000007487 | ENSGALP00000022956 | Chromosome segregation 1 like. | RanBD1 domain-containing protein. | 0.503 |
KPNA1 | CSE1L | ENSGALP00000034376 | ENSGALP00000007487 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Chromosome segregation 1 like. | 0.969 |
KPNA1 | KPNA3 | ENSGALP00000034376 | ENSGALP00000027423 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Importin subunit alpha; Belongs to the importin alpha family. | 0.944 |
KPNA1 | KPNA4 | ENSGALP00000034376 | ENSGALP00000056543 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Importin subunit alpha; Belongs to the importin alpha family. | 0.947 |
KPNA1 | KPNB1 | ENSGALP00000034376 | ENSGALP00000046659 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Karyopherin subunit beta 1. | 0.996 |
KPNA1 | NFKB1 | ENSGALP00000034376 | ENSGALP00000036814 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. | 0.912 |
KPNA1 | NUP50 | ENSGALP00000034376 | ENSGALP00000022956 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | RanBD1 domain-containing protein. | 0.966 |
KPNA1 | RELA | ENSGALP00000034376 | ENSGALP00000047666 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] | 0.927 |
KPNA1 | RNF10 | ENSGALP00000034376 | ENSGALP00000058296 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Ring finger protein 10. | 0.720 |
KPNA1 | STAT1 | ENSGALP00000034376 | ENSGALP00000046362 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Signal transducer and activator of transcription. | 0.813 |
KPNA1 | TERT | ENSGALP00000034376 | ENSGALP00000021506 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. | 0.742 |
KPNA3 | CSE1L | ENSGALP00000027423 | ENSGALP00000007487 | Importin subunit alpha; Belongs to the importin alpha family. | Chromosome segregation 1 like. | 0.968 |
KPNA3 | KPNA1 | ENSGALP00000027423 | ENSGALP00000034376 | Importin subunit alpha; Belongs to the importin alpha family. | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | 0.944 |
KPNA3 | KPNA4 | ENSGALP00000027423 | ENSGALP00000056543 | Importin subunit alpha; Belongs to the importin alpha family. | Importin subunit alpha; Belongs to the importin alpha family. | 0.964 |
KPNA3 | KPNB1 | ENSGALP00000027423 | ENSGALP00000046659 | Importin subunit alpha; Belongs to the importin alpha family. | Karyopherin subunit beta 1. | 0.875 |
KPNA3 | NFKB1 | ENSGALP00000027423 | ENSGALP00000036814 | Importin subunit alpha; Belongs to the importin alpha family. | Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. | 0.927 |