ASXL2 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ASXL2

Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...] (1550 aa)

Predicted Functional Partners:

BAP1

0.996

FOXK2

0.787

ASXL1

0.766

MLLT10

0.756

PCGF1

0.755

CBX8

0.755

RNF2

0.745

KDM1B

0.738

EZH1

0.708

ASXL3

0.706

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASXL1	ASXL2	ENSGALP00000010661	ENSGALP00000026627	ASXL transcriptional regulator 1.	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	0.766
ASXL1	ASXL3	ENSGALP00000010661	ENSGALP00000024470	ASXL transcriptional regulator 1.	ASXL transcriptional regulator 3.	0.638
ASXL1	BAP1	ENSGALP00000010661	ENSGALP00000006954	ASXL transcriptional regulator 1.	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	0.877
ASXL1	CBX8	ENSGALP00000010661	ENSGALP00000072650	ASXL transcriptional regulator 1.	Chromobox 8.	0.546
ASXL1	EZH1	ENSGALP00000010661	ENSGALP00000056397	ASXL transcriptional regulator 1.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.619
ASXL1	FOXK2	ENSGALP00000010661	ENSGALP00000002394	ASXL transcriptional regulator 1.	Forkhead box K2.	0.697
ASXL1	MLLT10	ENSGALP00000010661	ENSGALP00000012858	ASXL transcriptional regulator 1.	MLLT10 histone lysine methyltransferase DOT1L cofactor.	0.480
ASXL1	PCGF1	ENSGALP00000010661	ENSGALP00000065053	ASXL transcriptional regulator 1.	Polycomb group ring finger 1.	0.544
ASXL1	RNF2	ENSGALP00000010661	ENSGALP00000069071	ASXL transcriptional regulator 1.	Ring finger protein 2.	0.581
ASXL2	ASXL1	ENSGALP00000026627	ENSGALP00000010661	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	ASXL transcriptional regulator 1.	0.766
ASXL2	ASXL3	ENSGALP00000026627	ENSGALP00000024470	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	ASXL transcriptional regulator 3.	0.706
ASXL2	BAP1	ENSGALP00000026627	ENSGALP00000006954	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	0.996
ASXL2	CBX8	ENSGALP00000026627	ENSGALP00000072650	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Chromobox 8.	0.755
ASXL2	EZH1	ENSGALP00000026627	ENSGALP00000056397	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.708
ASXL2	FOXK2	ENSGALP00000026627	ENSGALP00000002394	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Forkhead box K2.	0.787
ASXL2	KDM1B	ENSGALP00000026627	ENSGALP00000020669	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Lysine demethylase 1B.	0.738
ASXL2	MLLT10	ENSGALP00000026627	ENSGALP00000012858	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	MLLT10 histone lysine methyltransferase DOT1L cofactor.	0.756
ASXL2	PCGF1	ENSGALP00000026627	ENSGALP00000065053	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Polycomb group ring finger 1.	0.755
ASXL2	RNF2	ENSGALP00000026627	ENSGALP00000069071	Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (B [...]	Ring finger protein 2.	0.745
ASXL3	ASXL1	ENSGALP00000024470	ENSGALP00000010661	ASXL transcriptional regulator 3.	ASXL transcriptional regulator 1.	0.638

page 1 of 4

Server load: low (40%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About