STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYCNN-myc proto-oncogene protein. (441 aa)    
Predicted Functional Partners:
MAX
Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity).
    
 
0.949
AURKA
Aurora kinase A; Belongs to the protein kinase superfamily.
   
 
 0.844
LTK
Tyrosine-protein kinase receptor.
    
 
 0.740
ALK
Tyrosine-protein kinase receptor.
    
 
 0.740
PHOX2B
Paired like homeobox 2B.
      
 0.718
E2F1
Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...]
    
 
 0.675
MXI1
BHLH domain-containing protein.
    
 
 0.670
LIN28B
Protein lin-28 homolog B; Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Belongs to the lin-28 family.
   
 
 0.659
NPC1
NPC intracellular cholesterol transporter 1.
   
 
 0.655
SCAP
SREBF chaperone.
   
 
 0.655
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.