node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ALDOB | ENSGALP00000060844 | ENSGALP00000036836 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Fructose-bisphosphate aldolase B. | 0.541 |
ACTB | GAPDH | ENSGALP00000060844 | ENSGALP00000063325 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.988 |
ACTB | PGK2 | ENSGALP00000060844 | ENSGALP00000012878 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. | 0.911 |
ACTB | PXDN | ENSGALP00000060844 | ENSGALP00000026363 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Peroxidasin. | 0.980 |
ACTB | PXDNL | ENSGALP00000060844 | ENSGALP00000049777 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Uncharacterized protein. | 0.980 |
ACTB | TKT | ENSGALP00000060844 | ENSGALP00000008498 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Transketolase. | 0.423 |
ACTB | TPI1 | ENSGALP00000060844 | ENSGALP00000023396 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.523 |
ALDOB | ACTB | ENSGALP00000036836 | ENSGALP00000060844 | Fructose-bisphosphate aldolase B. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.541 |
ALDOB | ALDOC | ENSGALP00000036836 | ENSGALP00000043256 | Fructose-bisphosphate aldolase B. | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | 0.902 |
ALDOB | GAPDH | ENSGALP00000036836 | ENSGALP00000063325 | Fructose-bisphosphate aldolase B. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.984 |
ALDOB | H6PD | ENSGALP00000036836 | ENSGALP00000003917 | Fructose-bisphosphate aldolase B. | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | 0.926 |
ALDOB | PGK2 | ENSGALP00000036836 | ENSGALP00000012878 | Fructose-bisphosphate aldolase B. | Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. | 0.799 |
ALDOB | TALDO1 | ENSGALP00000036836 | ENSGALP00000050308 | Fructose-bisphosphate aldolase B. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.964 |
ALDOB | TKT | ENSGALP00000036836 | ENSGALP00000008498 | Fructose-bisphosphate aldolase B. | Transketolase. | 0.993 |
ALDOB | TPI1 | ENSGALP00000036836 | ENSGALP00000023396 | Fructose-bisphosphate aldolase B. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.996 |
ALDOC | ALDOB | ENSGALP00000043256 | ENSGALP00000036836 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase B. | 0.902 |
ALDOC | GAPDH | ENSGALP00000043256 | ENSGALP00000063325 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.983 |
ALDOC | H6PD | ENSGALP00000043256 | ENSGALP00000003917 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | 0.923 |
ALDOC | PGK2 | ENSGALP00000043256 | ENSGALP00000012878 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. | 0.814 |
ALDOC | TALDO1 | ENSGALP00000043256 | ENSGALP00000050308 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.956 |