STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ROS1Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that may activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream si [...] (2311 aa)    
Predicted Functional Partners:
CEP85L
Centrosomal protein 85 like.
      
 0.705
EML4
EMAP like 4.
   
 
 0.659
GOPC
PDZ domain-containing protein.
    
 
 0.641
TDG
UDG domain-containing protein.
      
 0.587
KIAA1549
KIAA1549.
    
 
 0.565
MBD4
Uncharacterized protein.
    
 
 0.552
ALKAL2
ALK and LTK ligand 2.
    
 
 0.544
SLC34A2
Uncharacterized protein.
   
 
 0.504
CCDC6
Uncharacterized protein.
      
 0.483
MAP3K14
Protein kinase domain-containing protein.
    
 
 0.465
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.