node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIP | DCT | ENSGALP00000054181 | ENSGALP00000035733 | Agouti signaling protein. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.584 |
ASIP | MC1R | ENSGALP00000054181 | ENSGALP00000071620 | Agouti signaling protein. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | 0.999 |
ASIP | MITF | ENSGALP00000054181 | ENSGALP00000070157 | Agouti signaling protein. | BHLH domain-containing protein. | 0.744 |
ASIP | OCA2 | ENSGALP00000054181 | ENSGALP00000026970 | Agouti signaling protein. | OCA2 melanosomal transmembrane protein. | 0.745 |
ASIP | SLC24A5 | ENSGALP00000054181 | ENSGALP00000038183 | Agouti signaling protein. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.646 |
ASIP | SLC45A2 | ENSGALP00000054181 | ENSGALP00000005236 | Agouti signaling protein. | Uncharacterized protein. | 0.582 |
ASIP | TYRP1 | ENSGALP00000054181 | ENSGALP00000037537 | Agouti signaling protein. | 5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. | 0.860 |
DCT | ASIP | ENSGALP00000035733 | ENSGALP00000054181 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Agouti signaling protein. | 0.584 |
DCT | GPR143 | ENSGALP00000035733 | ENSGALP00000026765 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Uncharacterized protein. | 0.553 |
DCT | MC1R | ENSGALP00000035733 | ENSGALP00000071620 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | 0.768 |
DCT | MITF | ENSGALP00000035733 | ENSGALP00000070157 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | BHLH domain-containing protein. | 0.861 |
DCT | MLANA | ENSGALP00000035733 | ENSGALP00000030744 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melan-A. | 0.856 |
DCT | OCA2 | ENSGALP00000035733 | ENSGALP00000026970 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | OCA2 melanosomal transmembrane protein. | 0.638 |
DCT | PMEL | ENSGALP00000035733 | ENSGALP00000051268 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | 0.844 |
DCT | SLC24A5 | ENSGALP00000035733 | ENSGALP00000038183 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.653 |
DCT | SLC45A2 | ENSGALP00000035733 | ENSGALP00000005236 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Uncharacterized protein. | 0.781 |
DCT | TYRP1 | ENSGALP00000035733 | ENSGALP00000037537 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. | 0.941 |
GPR143 | DCT | ENSGALP00000026765 | ENSGALP00000035733 | Uncharacterized protein. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.553 |
GPR143 | MLANA | ENSGALP00000026765 | ENSGALP00000030744 | Uncharacterized protein. | Melan-A. | 0.736 |
GPR143 | OCA2 | ENSGALP00000026765 | ENSGALP00000026970 | Uncharacterized protein. | OCA2 melanosomal transmembrane protein. | 0.639 |