STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)    
Predicted Functional Partners:
MAPK3
Mitogen-activated protein kinase.
   
 0.956
FGF8
Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.
   
  
 0.785
SPRY2
Protein sprouty homolog 2; May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 through participation in a regulatory negative feedback loop.
   
  
 0.783
SPRY4
Sprouty RTK signaling antagonist 4.
   
  
 0.770
LOC100858386
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.733
IL17RD
Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).
   
  
 0.717
FGF18
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.676
FGF5
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
  
 0.617
FGF19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
  
 0.616
FGF20
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.615
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.