node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS4 | ENSGALP00000010867 | ENSGALP00000047303 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 4. | 0.919 |
ACAN | ADAMTS5 | ENSGALP00000010867 | ENSGALP00000025424 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.901 |
ACAN | COL2A1 | ENSGALP00000010867 | ENSGALP00000052906 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.952 |
ACAN | COL3A1 | ENSGALP00000010867 | ENSGALP00000051057 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.990 |
ACAN | COMP | ENSGALP00000010867 | ENSGALP00000005183 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Uncharacterized protein. | 0.934 |
ACAN | DCN | ENSGALP00000010867 | ENSGALP00000062069 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.931 |
ACAN | FMOD | ENSGALP00000010867 | ENSGALP00000043794 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.931 |
ACAN | HAPLN1 | ENSGALP00000010867 | ENSGALP00000072418 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. | 0.980 |
ACAN | SOX9 | ENSGALP00000010867 | ENSGALP00000037718 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.955 |
ACAN | TNR | ENSGALP00000010867 | ENSGALP00000062658 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. | 0.947 |
ADAMTS4 | ACAN | ENSGALP00000047303 | ENSGALP00000010867 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.919 |
ADAMTS4 | ADAMTS5 | ENSGALP00000047303 | ENSGALP00000025424 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.549 |
ADAMTS4 | COL2A1 | ENSGALP00000047303 | ENSGALP00000052906 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.488 |
ADAMTS4 | COL3A1 | ENSGALP00000047303 | ENSGALP00000051057 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.606 |
ADAMTS4 | SOX9 | ENSGALP00000047303 | ENSGALP00000037718 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] | 0.472 |
ADAMTS5 | ACAN | ENSGALP00000025424 | ENSGALP00000010867 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.901 |
ADAMTS5 | ADAMTS4 | ENSGALP00000025424 | ENSGALP00000047303 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | ADAM metallopeptidase with thrombospondin type 1 motif 4. | 0.549 |
ADAMTS5 | COL2A1 | ENSGALP00000025424 | ENSGALP00000052906 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.608 |
ADAMTS5 | COL3A1 | ENSGALP00000025424 | ENSGALP00000051057 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.708 |
ADAMTS5 | COMP | ENSGALP00000025424 | ENSGALP00000005183 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Uncharacterized protein. | 0.400 |