STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSFL1CNSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (379 aa)    
Predicted Functional Partners:
UBXN6
UBX domain protein 6.
    
 0.995
UBXN2A
Uncharacterized protein.
  
 
0.992
VCP
Valosin containing protein.
   
 0.981
VCPIP1
OTU domain-containing protein.
   
 
 0.965
UFD1L
Ubiquitin fusion-degradation 1-like protein.
   
 
 0.961
ASPSCR1
ASPSCR1 tether for SLC2A4, UBX domain containing.
    
 
 0.959
FAF1
Fas associated factor 1.
   
 
 0.946
UBXN7
UBX domain protein 7.
    
 
 0.946
UBXN10
UBX domain protein 10.
    
 
 0.944
UBXN4
Uncharacterized protein.
    
 0.935
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.