node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | COL6A1 | ENSGALP00000056897 | ENSGALP00000057372 | Link domain-containing protein. | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | 0.912 |
CD44 | COL6A2 | ENSGALP00000056897 | ENSGALP00000043563 | Link domain-containing protein. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.909 |
CD44 | DCN | ENSGALP00000056897 | ENSGALP00000062069 | Link domain-containing protein. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.411 |
CD44 | ITGAV | ENSGALP00000056897 | ENSGALP00000047574 | Link domain-containing protein. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.520 |
CD44 | ITGB1 | ENSGALP00000056897 | ENSGALP00000054354 | Link domain-containing protein. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.516 |
CD44 | ITGB3 | ENSGALP00000056897 | ENSGALP00000000518 | Link domain-containing protein. | Integrin beta; Belongs to the integrin beta chain family. | 0.497 |
COL6A1 | CD44 | ENSGALP00000057372 | ENSGALP00000056897 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Link domain-containing protein. | 0.912 |
COL6A1 | COL6A2 | ENSGALP00000057372 | ENSGALP00000043563 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.989 |
COL6A1 | DCN | ENSGALP00000057372 | ENSGALP00000062069 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.778 |
COL6A1 | ITGA11 | ENSGALP00000057372 | ENSGALP00000012982 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. | 0.772 |
COL6A1 | ITGA8 | ENSGALP00000057372 | ENSGALP00000065785 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.764 |
COL6A1 | ITGAV | ENSGALP00000057372 | ENSGALP00000047574 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.760 |
COL6A1 | ITGB1 | ENSGALP00000057372 | ENSGALP00000054354 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.929 |
COL6A1 | ITGB3 | ENSGALP00000057372 | ENSGALP00000000518 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta; Belongs to the integrin beta chain family. | 0.731 |
COL6A1 | ITGB5 | ENSGALP00000057372 | ENSGALP00000047825 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin beta; Belongs to the integrin beta chain family. | 0.754 |
COL6A1 | PELO | ENSGALP00000057372 | ENSGALP00000023976 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | 0.775 |
COL6A2 | CD44 | ENSGALP00000043563 | ENSGALP00000056897 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Link domain-containing protein. | 0.909 |
COL6A2 | COL6A1 | ENSGALP00000043563 | ENSGALP00000057372 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. | 0.989 |
COL6A2 | DCN | ENSGALP00000043563 | ENSGALP00000062069 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.569 |
COL6A2 | ITGA11 | ENSGALP00000043563 | ENSGALP00000012982 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. | 0.711 |