node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMT | CYP1A1 | ENSGALP00000070206 | ENSGALP00000039219 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.954 |
COMT | CYP1A2 | ENSGALP00000070206 | ENSGALP00000002016 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.929 |
COMT | UGT1A1 | ENSGALP00000070206 | ENSGALP00000006662 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.912 |
CYP19A1 | CYP1A1 | ENSGALP00000066452 | ENSGALP00000039219 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.949 |
CYP19A1 | CYP1A2 | ENSGALP00000066452 | ENSGALP00000002016 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.946 |
CYP19A1 | CYP3A4 | ENSGALP00000066452 | ENSGALP00000007048 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.943 |
CYP19A1 | CYP3A5 | ENSGALP00000066452 | ENSGALP00000007068 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Uncharacterized protein. | 0.943 |
CYP19A1 | CYP7A1 | ENSGALP00000066452 | ENSGALP00000054104 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.684 |
CYP19A1 | HSD17B7 | ENSGALP00000066452 | ENSGALP00000057452 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Uncharacterized protein. | 0.939 |
CYP19A1 | UGT1A1 | ENSGALP00000066452 | ENSGALP00000006662 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.931 |
CYP1A1 | COMT | ENSGALP00000039219 | ENSGALP00000070206 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.954 |
CYP1A1 | CYP19A1 | ENSGALP00000039219 | ENSGALP00000066452 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.949 |
CYP1A1 | CYP1A2 | ENSGALP00000039219 | ENSGALP00000002016 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.958 |
CYP1A1 | CYP3A4 | ENSGALP00000039219 | ENSGALP00000007048 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.960 |
CYP1A1 | CYP3A5 | ENSGALP00000039219 | ENSGALP00000007068 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Uncharacterized protein. | 0.970 |
CYP1A1 | CYP7A1 | ENSGALP00000039219 | ENSGALP00000054104 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.970 |
CYP1A1 | EPHX1 | ENSGALP00000039219 | ENSGALP00000015099 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.972 |
CYP1A1 | EPHX1L | ENSGALP00000039219 | ENSGALP00000016743 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | EHN domain-containing protein. | 0.962 |
CYP1A1 | HSD17B7 | ENSGALP00000039219 | ENSGALP00000057452 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Uncharacterized protein. | 0.954 |
CYP1A1 | UGT1A1 | ENSGALP00000039219 | ENSGALP00000006662 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.978 |